The Scientific Legacy of Har Gobind Khorana: Total Synthesis and the Genetic Code

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Sahotra Sarkar

The Scientific Legacy of Har Gobind Khorana

Total Synthesis and the Genetic Code

Sahotra Sarkar

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Hardback

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English

Anthem Press
13 August 2024

Biography: science, technology & engineering; Molecular biology

This book is the only scientific biography of the Nobel Prizewinning Indian American chemist, Har Gobind Khorana.

It begins with the story of Khorana's origins in poverty in rural India and how he manages to emerge from that to be trained in chemistry in Britain and Switzerland before immigrating to Canada and the United States. Science was the dominant focus of Khorana's life, and his biography is treated chronologically in conjunction with his scientific career.

The book explains in detail Khorana's most important scientific achievements, his role in deciphering the genetic code (the reason for his Nobel Prize), the first synthesis of a functional gene in the laboratory, the elucidation of the idea behind the PCR technology that has since become ubiquitous in biotech, and his seminal studies of how structure determines the function of biological macromolecules in membranes. Finally, it focuses on his scientific legacy, and what his career means for future generations of scientists.

By: Sahotra Sarkar
Imprint: Anthem Press
Country of Publication: United Kingdom
Dimensions: Height: 229mm, Width: 153mm, Spine: 13mm
Weight: 454g
ISBN: 9781839992322
ISBN 10: 1839992328
Pages: 144
Publication Date: 13 August 2024
Audience: Professional and scholarly , Undergraduate
Format: Hardback
Publisher's Status: Active

Sahotra Sarkar is Professor in the Departments of Philosophy and Integrative Biology at the University of Texas at Austin.

Reviews for The Scientific Legacy of Har Gobind Khorana: Total Synthesis and the Genetic Code

“How is it possible that a young man from an impoverished village in South Asia would go on to lay the foundations of modern chemical biology—from cracking the genetic code to DNA gene synthesis? In a testimonial to the spirit of human perseverance, Sarkar paints an engaging and detailed portrait of the life and work of H.G. Khorana, one of the great scientists of the twentieth century.” — Thomas P. Sakmar, M.D., Richard M. and Isabel P. Furlaud Professor, The Rockefeller University, New York, NY, USA “This book provides the first book-length account of the work and life of the Indian-American scientist Har Gobind Khorana. On the basis of firsthand interviews, Sarkar does a great job explaining the ‘chemical biology’ pioneered by this pivotal figure of the 20th-century life sciences and provides clues as to why Khorana was neglected for so long.” — Mathias Grote, University of Greifswald