Medicinal Chemistry and Drug Development describes the key events and roles of medicinal chemistry in the discovery and development of lead compounds into drugs, including target identification, which is accomplished by using 30 case studies. This book outlines all the stages of drug development, including the discovery of active compounds, research on the pharmacological properties of molecules, and confirmation of drug targets. The role of the case studies is to show the common factors in the successful development of drugs, thereby showing medicinal chemists how best to explore the scientific pathways when developing new drugs. This makes the book especially relevant for senior university students majoring in pharmaceutical sciences as well as graduate students and researchers.
Edited by:
Gang Liu PhD (Tsinghua University)
Imprint: Elsevier - Health Sciences Division
Country of Publication: United States
Dimensions:
Height: 276mm,
Width: 216mm,
Weight: 450g
ISBN: 9780443274022
ISBN 10: 0443274029
Pages: 804
Publication Date: 17 February 2025
Audience:
Professional and scholarly
,
Undergraduate
Format: Paperback
Publisher's Status: Active
1. Medicinal chemistry and product process development of Sitagliptin, a drug for anti type 2 Diabetes. 2. Insulin 3. GLP-1 receptor agonist for drug development 4. Antidiabetic drugs development based on sodium-glucose cotransporter 2 (SGLT2) inhibitors: Dapagliflozin 5. Atorvastatin, a cholesterol-reducing drug 6. Discovery of Angiotensin II receptor blockers for hypertension: Losartan and its analogues 7. Apixaban, an antithrombotic drug for thrombosis 8. Fondaparinux, an anticoagulant drug 9. Development of Sofosbuvir, an antiviral nucleoside for HCV 10. Discovery and development of Raltegravir, the first HIV-1 integrase inhibitor 11. Discovery and development of Saquinavir, an HIV protease inhibitor 12. Baloxavir Marboxil, a novel anti-influenza drug 13. Taxol, a natural antitumor drug 14. Eltrombopag, an natural derivative of antitumor drug 15. Imatinib, a tyrosine kinase inhibitor for cancer treatment 16. Afatinib, an irreversible covalent EGFR inhibitor for cancer treatment 17. Tamoxifen, an anticancer drug for breast cancer 18. Fluconazole, a triazole antifungal drug 19. Linaclotide, an oxazolidinone class antibacterial drug 20. Meropenema carbapenem class antibacterial drug 21. Antiparasitic drug pyrroloquinoline quinone 22. Proton pump inhibitor Omeprazole 23. Discovery of PDE5 inhibitors for the treatment of erectile dysfunction and pulmonary arterial hypertension 24. GABAA receptor agonists: discovery of the general anesthetic Propofol and its analogs 25. Discovery of multitarget drug Risperidone 26. First ani-renal anemia drug Roxadustat 27. The splendid transformation process of a natural product: function, medicinal research, and development process of natural (+)-Calanolide A 28. Bone-specific targeted drug Bisphosphonate 29. Selective COX-2 inhibitor Celecoxib 30. Examples of antisense nucleotide drugs for the treatment of Duchenne muscular dystrophy
Professor Gang Liu has been engaged in research on medicinal chemistry and chemical biology for over 30 years. He studied at The Scripps Research Institute and the University of California, Davis in the United States. Since 2011, he has been a ""Tenure-Track Professor"" at Tsinghua University, Vice Dean of School of Medicine, and was responsible for the establishment of the Department of Pharmaceutical Sciences (now the School of Pharmaceutical Sciences) at Tsinghua University.
