Small Molecules in Neurodegeneration

Nawab John Dar, Shahnawaz Ali Bhat

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English

CRC Press
13 March 2025

Physiological & neuro-psychology, biopsychology; Neurology & clinical neurophysiology; Pathology; Pharmacology; Neurosciences

Neurodegenerative diseases, like Alzheimer's, Parkinson's, and Huntington's, cast a long shadow over millions of lives, stealing memories, independence, and futures. The rising tide of these age-related disorders threatens to overwhelm healthcare systems worldwide, prompting an urgent search for effective treatments. While current options offer temporary relief, they fail to halt the relentless march of these devastating conditions. However, a beacon of hope shines at the intersection of cutting-edge neuroscience and the world of small molecules. These tiny chemical warriors, with their inherent advantages of cost-effectiveness, scalability, and diverse functionalities, are emerging as powerful weapons in the fight against neurodegeneration. This book stands as a testament to this increasing revolution. It investigates deep into the intricacies of small molecules, exploring their potential to unravel the mysteries of neurodegenerative diseases and pave the way for innovative therapeutic interventions.

Key Features:

Provides a comprehensive and accessible overview of the emerging field of small molecules in neurodegenerative diseases. Bridges the gap in current literature by addressing the specific impact of small molecules on these devastating conditions. Offers an in-depth exploration of the various mechanisms by which small molecules can combat neurodegeneration. Serves as a valuable resource for a wide audience, from students to professionals in the field. Lays the foundation for a deeper understanding of neurodegenerative diseases and unlocks new avenues for the development of effective therapies.

Edited by: Nawab John Dar, Shahnawaz Ali Bhat
Imprint: CRC Press
Country of Publication: United Kingdom
Dimensions: Height: 254mm, Width: 178mm,
ISBN: 9781032857282
ISBN 10: 1032857285
Pages: 274
Publication Date: 13 March 2025
Audience: College/higher education , Professional and scholarly , Primary , Undergraduate
Format: Hardback
Publisher's Status: Forthcoming

Chapter 1. Introduction to Neurodegenerative Diseases. Chapter 2. Small molecules: An emerging therapeutic frontier. Chapter 3. Small molecules in multiple sclerosis: An update. Chapter 4. Andrographolide in Neurological Disorders: a detailed overview. Chapter 5. Natural Products as Neuroprotective Agents. Chapter 6. Medicinal Chemistry and the Design of Small Molecules. Chapter 7. Neurotrophic Factors and Small Molecule Mimetics. Chapter 8. Repurposed Drugs: Expanding the Therapeutic Resource. Chapter 9. Integrating Small Molecules into Multimodal Treatment Strategies. Chapter 10. Advances in Small Molecule Delivery Systems for the Treatment of Neurodegenerative Disease. Chapter 11. An Enigmatic role of Small Molecule Therapeutics in Neurodegeneration. Chapter 12. Bridging the Gap in Neurodegenerative Disease Therapy (NDT). Chapter 13. Ethical and Economic Considerations in Small Molecule Therapy.

Dr. Nawab John Dar is at the Salk Institute for Biological Studies in La Jolla, California, where he is part of a research group led by Professor Pamela Maher. His research journey began after graduating from the CSIR-Indian Institute of Integrative Medicine in India, and he has since been dedicated to advancing the understanding of neurodegenerative disorders, particularly Alzheimer’s disease. Dr. Dar's work focuses on exploring the neuroprotective potential of bioactive compounds and investigating the role of oxytosis/ferroptosis in Alzheimer’s disease. His goal is to identify targets for effective therapies against Alzheimer’s. Beyond his scientific endeavors, Dr. Dar is a committed educator and advocate for raising awareness about neurodegenerative diseases, emphasizing the importance of small molecules in targeting various aspects of neurodegeneration. His work not only sheds light on the potential of these molecules but also offers hope for effective treatments for millions affected by these conditions. Dr. Shahnawaz Ali Bhat is an Assistant Professor in the Department of Zoology at Aligarh Muslim University (AMU), Aligarh, India. Currently his research program focuses on deciphering the molecular and cellular processes/pathways involved in the pathogenesis of neurodegenerative diseases and metabolic disorders. Further, he is also interested in neuropharmacological and neurotoxicological studies to screen or identify various bioactive molecules for effective prevention of neurodegenerative diseases and hypertension-induced neurodegeneration.