Immunological Bioinformatics

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Ole Lund (Ctr Biological Sequence Analys) Morten Nielsen (Ctr Biological Sequence Analys)

Immunological Bioinformatics

Ole Lund (Ctr Biological Sequence Analys), Morten Nielsen (Ctr Biological Sequence Analys), Claus Lundegaard (Ctr Biological Sequence Analys) , Can Kesmir (Utrecht University)

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English

MIT Press
06 February 2024

Biochemical immunology; Molecular biology; Biotechnology

Series: Computational Molecular Biology

Using bioinformatics methods to generate a systems-level view of the immune system; description of the main biological concepts and the new data-driven algorithms.

Using bioinformatics methods to generate a systems-level view of the immune system; description of the main biological concepts and the new data-driven algorithms.

Despite the fact that advanced bioinformatics methodologies have not been used as extensively in immunology as in other subdisciplines within biology, research in immunological bioinformatics has already developed models of components of the immune system that can be combined and that may help develop therapies, vaccines, and diagnostic tools for such diseases as AIDS, malaria, and cancer. In a broader perspective, specialized bioinformatics methods in immunology make possible for the first time a systems-level understanding of the immune system. The traditional approaches to immunology are reductionist, avoiding complexity but providing detailed knowledge of a single event, cell, or molecular entity. Today, a variety of experimental bioinformatics techniques connected to the sequencing of the human genome provides a sound scientific basis for a comprehensive description of the complex immunological processes. This book offers a description of bioinformatics techniques as they are applied to immunology, including a succinct account of the main biological concepts for students and researchers with backgrounds in mathematics, statistics, and computer science as well as explanations of the new data-driven algorithms in the context of biological data that will be useful for immunologists, biologists, and biochemists working on vaccine design. In each chapter the authors show interesting biological insights gained from the bioinformatics approach. The book concludes by explaining how all the methods presented in the book can be integrated to identify immunogenic regions in microorganisms and host genomes.

By: Ole Lund (Ctr Biological Sequence Analys), Morten Nielsen (Ctr Biological Sequence Analys), Claus Lundegaard (Ctr Biological Sequence Analys), Can Kesmir (Utrecht University), Søren Brunak (Technical University of Denmark)
Imprint: MIT Press
Country of Publication: United States
Dimensions: Height: 229mm, Width: 178mm,
Weight: 369g
ISBN: 9780262551120
ISBN 10: 0262551128
Series: Computational Molecular Biology
Pages: 312
Publication Date: 06 February 2024
Recommended Age: From 18 years
Audience: Professional and scholarly , Undergraduate
Format: Paperback
Publisher's Status: Active

Ole Lund is Associate Professor and leader of the Immunological Bioinformatics group at the Center for Biological Sequence Analysis at Technical University of Denmark. Morten Nielsen is Associate Professor at the Center for Biological Sequence Analysis at Technical University of Denmark. Claus Lundegaard is Associate Professor at the Center for Biological Sequence Analysis at Technical University of Denmark. Can Kesmir is Assistant Professor in the Department of Theoretical Biology at Utrecht University. S ren Brunak is Professor and Director of the Center for Biological Sequence Analysis at the Technical University of Denmark.