PAUL H. GAMACHE is Director of Research and Development at Thermo Fisher Scientific. He has more than thirty years' experience within the analytical instrument industry. His primary area of expertise is in the development of instrumentation and techniques based on liquid chromatography. He has published more than 50 articles and book chapters including the first publication describing commercial CAD technology. In 2005 he was co-awardee of an NIH Metabolomics Roadmap research grant.