What Is Health?

Allostasis and the Evolution of Human Design

Peter Sterling

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Hardback

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English

MIT Press
25 February 2020

Neurology & clinical neurophysiology; Mathematics & Sciences; Evolution; Neurosciences

Series: The MIT Press

An argument that health is optimal responsiveness and is often best treated at the system level.

Medical education centers on the venerable ""no-fault"" concept of homeostasis, whereby local mechanisms impose constancy by correcting errors, and the brain serves mainly for emergencies. Yet, it turns out that most parameters are not constant; moreover, despite the importance of local mechanisms, the brain is definitely in charge. In this book, the eminent neuroscientist Peter Sterling describes a broader concept- allostasis (coined by Sterling and Joseph Eyer in the 1980s), whereby the brain anticipates needs and efficiently mobilizes supplies to prevent errors.

Allostasis evolved early, Sterling explains, to optimize energy efficiency, relying heavily on brain circuits that deliver a brief reward for each positive surprise. Modern life so reduces the opportunities for surprise that we are driven to seek it in consumption- bigger burgers, more opioids, and innumerable activities that involve higher carbon emissions. The consequences include addiction, obesity, type 2 diabetes, and climate change. Sterling concludes that solutions must go beyond the merely technical to restore possibilities for daily small rewards and revivify the capacities for egalitarianism that were hard-wired into our nature.

Sterling explains that allostasis offers what is not found in any medical textbook- principled definitions of health and disease- health as the capacity for adaptive variation and disease as shrinkage of that capacity. Sterling argues that since health is optimal responsiveness, many significant conditions are best treated at the system level.

By: Peter Sterling
Imprint: MIT Press
Country of Publication: United States
Dimensions: Height: 229mm, Width: 152mm, Spine: 22mm
ISBN: 9780262043304
ISBN 10: 0262043300
Series: The MIT Press
Pages: 264
Publication Date: 25 February 2020
Audience: Professional and scholarly , Undergraduate
Format: Hardback
Publisher's Status: Active

Peter Sterling is Professor of Neuroscience at the University of Pennsylvania School of Medicine. He is the coauthor (with Simon Laughlin) of Principles of Neural Design (MIT Press).