Transposable Elements and Genome Evolution

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Aurélie Hua-Van (Paris-Saclay University, France) Pierre Capy (Paris-Saclay University, France)

Transposable Elements and Genome Evolution

Aurélie Hua-Van (Paris-Saclay University, France), Pierre Capy (Paris-Saclay University, France)

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English

ISTE Ltd
17 September 2024

Genetics (non-medical); Developmental biology

Series: ISTE Consignment

Since their discovery by Barbara McClintock in the mid-20th century, the importance of transposable elements in shaping the architecture, function and evolution of genomes has gradually been unveiled.

These DNA sequences populate nearly all genomes and are viewed as genomic parasites. They are mobile, capable of proliferating within genomes and also commonly travel between species.

These elements are mutagenic and are responsible for several human genetic disorders, but they also constitute a major source of genetic diversity. Some insertions have beneficial effects for the host and are selected for, giving rise to significant evolutionary innovations. Their dynamics within genomes are intricate, as are their interactions with other genome components. To limit their proliferation, the genome has evolved sophisticated defense mechanisms.

While researchers commonly use these elements as genetic tools, their identification in newly sequenced genomes remains a challenge due not only to their extensive diversity, but also their large copy numbers.

Edited by: Aurélie Hua-Van (Paris-Saclay University France), Pierre Capy (Paris-Saclay University, France)
Imprint: ISTE Ltd
Country of Publication: United Kingdom
ISBN: 9781789451788
ISBN 10: 1789451787
Series: ISTE Consignment
Pages: 304
Publication Date: 17 September 2024
Audience: Professional and scholarly , Undergraduate
Format: Hardback
Publisher's Status: Forthcoming

Aurélie Hua-Van is Professor of Biology at Paris-Saclay University, France. She teaches in various domains such as genetics, evolution, life origin and bioinformatics. Her research focuses on eukaryotic transposable elements evolution and dynamics, through experimental evolution and genomics. Pierre Capy is a former Professor of Biology at Paris-Saclay University, France. He taught evolutionary biology, quantitative genetics and genome plasticity, and always tried to create bridges between ecology and molecular biology. It is within this context that his research on transposable elements is placed.