Theory, Techniques and Applications of Nanotechnology in Gene Silencing

Surendra Nimesh, Ramesh Chandra

$221

Hardback

Not in-store but you can order this
How long will it take?

Availability Information

We source books from suppliers in Australia and overseas. For books we don't currently have in stock, the time it takes to get them from our suppliers can vary widely - from a few days to a few months - so we check each book with each supplier to determine the expected time it will take to be supplied to us.

We then advise you accordingly. If the time taken to get any book is too long for you, you can let us know and we will cancel or adjust your order, and refund as required.

To find out the anticipated arrival time for specific items prior to ordering, please contact us by phone or email:

Phone +61 2 9264 3111, or 1800 4 BOOKS (1800 4 26657) if outside Sydney:
option 1 Abbey's Bookshop (Crime, History, Science, Kids & more) • info@abbeys.com.au
option 2 Language Book Centre (ESL & Foreign Languages) • language@abbeys.com.au
option 3 Galaxy Bookshop (Sci-fi, Fantasy, Romance, Graphic Novels) • sf@galaxybooks.com.au

QTY:

English

River Publishers
06 February 2012

Biology, life sciences; Nanotechnology; Biotechnology; Environmental science, engineering & technology

Gene silencing mediated through short interfering RNAs (siRNAs) is rapidly emerging as a new class of therapeutics for the treatment of inherited and acquired diseases. However, poor cellular uptake and instability in physiological conditions limits its therapeutic potential, hence there arises a need to develop a delivery system which can protect and efficiently transport siRNA to the target cells. Nanotechnology based non-viral vectors have been proposed as a potential alternate. Various polymeric nanoparticles have been shown as suitable delivery candidates with high cellular uptake efficiencies and advantage of reduced cytotoxicity. These delivery vectors form condensed complexes with siRNA which in turn provides protection to siRNA from enzymatic degradation and further leads to enhanced tissue and cellular targeting. Nanoparticles prepared from various polymers like polyethylenimine, chitosan have been largely exploited, as they bear several advantages such as, easy manipulatibility, high stability, low cost and high payload. Though numerous publications have appeared in the literature, there was still need to get more information under one roof, as book compilation which could provide a systematic account of all the aspects of nanotechnology mediated gene silencing right from the preparation of nanoparticles to in vitro and in vivo characterization followed by various applications in vitro and in vivo models. This book focuses on various aspects of nanotechnology based gene silencing. The initial chapters detail the techniques available for in vitro and in vivo characterization of nanoparticles. In the later chapters, exhaustive details about various polymeric systems employed for gene silencing has been accounted.

The important topics discussed in the book include:-• Introduction to Nanotechnology• Physicochemical? Characterization of Nanoparticles• In Vitro and In Vivo Characterization of Nanoparticles• Concept and Barriers to Gene Silencing• Nanoparticles Mediated Targeted siRNA delivery• Polymers for siRNA Delivery• Chitosan• Polyethylenimine• Poly-L-lysine• Atelocollagen• Protamine• Dendrimers• Cyclodextrin• Poly (D, L-lactide-co-glycolide)• Nanomaterials for siRNA delivery; Keyword Index

By: Surendra Nimesh, Ramesh Chandra
Imprint: River Publishers
Country of Publication: Denmark
Dimensions: Height: 234mm, Width: 156mm, Spine: 17mm
Weight: 453g
ISBN: 9788792329837
ISBN 10: 8792329837
Pages: 218
Publication Date: 06 February 2012
Audience: Professional and scholarly , Undergraduate
Format: Hardback
Publisher's Status: Active

1 Introduction to Nanotechnology 2 Physicochemical Characterization of Nanoparticles 3 In Vitro and In Vivo Characterization of Nanoparticles 4 Concept and Barriers to Gene Silencing 5 Nanoparticles-Mediated Targeted siRNA Delivery 6 Polymers for siRNA Delivery 7 Chitosan 8 Polyethylenimine 9 Poly-L-lysine 10 Atelocollagen 11 Protamine 12 Dendrimers 13 Cyclodextrin 14 Poly (D, L-Lactide-co-Glycolide) 15 Nanomaterials for siRNA Delivery

Ramesh Chandra, Surendra Nimesh

Reviews for Theory, Techniques and Applications of Nanotechnology in Gene Silencing

Nanotechnology, and its products nanomaterials, has acquired important scientific, technical and commercial value for the production of products with improved performance characteristics. The field of medicine has been no exception, and intense scientific activity in this area is currently underway worldwide, and a few products with improved delivery parameter claims have reached the market. This book by Dr. Surendra Nimesh and Prof. Ramesh Chandra has special emphasis on gene silencing. Gene silencing, that is thwarting or down regulating a particular gene expression, has acquired significance in tackling certain human diseases, especially by invoking RNA interference (RNAi). This book has been beautifully organized. The first three Chapters deal with nanotechnology and nanoparticles. Next the concept and barriers to gene silencing is discussed in some detail covering essentially small interfering RNA (siRNA). Rest of the book deals essentially with the delivery of siRNA by natural and synthetic polymers, as well as inorganic nanoparticles as carriers. This book provides an excellent introduction for a beginner interested in this important area of therapeutics technology, as well as for the expert to get a rapid present overview of this science. Dr. Sukh Dev, FNA INSA- S.N.Bose Research Professor Dr. B.R. Ambedkar Center for Biomedical Research University of Delhi, Delhi-110007, India