The Evolution of Immunotherapy Against Tumors: An Historical Approach

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Domenico Ribatti (Full Professor of Human Anatomy, University of Bari Medical School, Bari, Italy)

The Evolution of Immunotherapy Against Tumors

An Historical Approach

Domenico Ribatti (Full Professor of Human Anatomy, University of Bari Medical School, Bari, Italy)

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English

Academic Press Inc
20 September 2024

Operational research; Biology, life sciences; Enterprise software

The Evolution of Immunotherapy Against Tumors: An Historical Approach summarizes the literature concerning the development of the theory of immune surveillance against tumors. It discusses the evidence for and against this theory, along with the concept of immunoediting. Finally, current approaches in anti-tumor immunotherapy will be analyzed.

The immune system plays a major role in the surveillance against tumors. To avoid attack from the immune system, tumor cells develop different strategies to escape immune surveillance. Evidence of immune surveillance comes from both animal models and clinical observations. Mice with a wide variety of immunodeficiencies have a high rate of tumor incidence and are more susceptible to transplanted or chemical carcinogen-induced tumors. Immunosuppressed patients have a high incidence of tumors. However, many patients develop cancer even in the presence of an apparently normal immune system. This indicates that tumor cells can escape immune surveillance.

By: Domenico Ribatti (Full Professor of Human Anatomy University of Bari Medical School Bari Italy)
Imprint: Academic Press Inc
Country of Publication: United States
Dimensions: Height: 229mm, Width: 152mm,
Weight: 450g
ISBN: 9780443217982
ISBN 10: 044321798X
Pages: 194
Publication Date: 20 September 2024
Audience: Professional and scholarly , Undergraduate
Format: Paperback
Publisher's Status: Active

Domenico Ribatti was awarded his M.D. degree in October 1981, with full marks. In 1983, D.R. joined the Medical School as Assistant at the Institute of Human Anatomy, University of Bari. In 1984, he took the specialization in Allergology. In 1989, he spent one year in Geneva, working at the Department of Morphology (Prof. R. Montesano). In 2008, he received the honoris causa degree in Medicine and Pharmacy form the University of Timisoara (Romania). D.R. is author of 866 publications as reported in PUBmed and contributed to 50 chapters to books. Overall, his papers have been cited 51153 times. He has published many books with both Elsevier and Springe