Targeted Metallo-Drugs: Design, Development, and Modes of Action

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Etelka Farkas (University of Debrecen) Celine J. Marmion (RCSI University of Medicine and Health Sciences)

Targeted Metallo-Drugs

Design, Development, and Modes of Action

Etelka Farkas (University of Debrecen), Celine J. Marmion (RCSI University of Medicine and Health Sciences)

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English

CRC Press
15 May 2023

Inorganic chemistry; Biochemistry; Pharmaceutical technology

Series: Metal Ions in Life Sciences Series

Volume 24, entitled Targeted Metallo-Drugs: Design, Development, and Modes of Action, of the series Metal Ions in Life Sciences (MILS), fosters inter-disciplinary research in the vibrant field of Biological Inorganic Chemistry. Inspired by the clinical success of cisplatin as a leading anticancer drug but mindful of the shortcomings associated with its use including dose-limiting toxic side effects and acquired or intrinsic drug resistance, scientists across the globe have been endeavoring to identify new metallo-drugs for therapeutic exploitation. This has led to innovative metallo-drug candidates that (i) enhance cancer cell selectivity, thus reducing toxic side effects, and/or (ii) possess new modes of action to improve efficacy and also target resistance pathways. This and more are captured in MILS- 24 which consists of 12 comprehensive, well-illustrated, and up to date chapters with over 1600 citations, 100 figures, and 10 tables with key contributions from 32 international experts from Europe, Asia, and North and South America. MILS- 24 not only keeps the scientific community abreast of latest developments, it also serves as an invaluable resource to stimulate further research on targeted metallo-drug design and development.

It covers anticancer, antimicrobial, antiviral, and other agents, such as those targeting tropical diseases and cyanide poisoning and radiometals in molecular imaging and therapy It highlights recent metallo-drug developments targeting COVID-19 It features advanced spectroscopic methods and metallomics as important tools to elucidate the modes of actions of metallo-drugs

Edited by: Etelka Farkas (University of Debrecen), Celine J. Marmion (RCSI University of Medicine and Health Sciences)
Imprint: CRC Press
Country of Publication: United Kingdom
Dimensions: Height: 229mm, Width: 152mm,
Weight: 800g
ISBN: 9781032223308
ISBN 10: 1032223308
Series: Metal Ions in Life Sciences Series
Pages: 370
Publication Date: 15 May 2023
Audience: College/higher education , Professional and scholarly , Primary , Undergraduate
Format: Hardback
Publisher's Status: Active

Etelka Farkas, Celine J. Marmion