Sustainable Quality Improvements for Isotope Dilution in Molecular Ultratrace Analyses: Fitness for Purpose,...

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Yves Tondeur (Founder and CEO, It’s About Purpose, LLC, USA)

Sustainable Quality Improvements for Isotope Dilution in Molecular Ultratrace Analyses

Fitness for Purpose, Performance-Based Criteria, and Measurement Uncertainty

Yves Tondeur (Founder and CEO, It’s About Purpose, LLC, USA)

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English

Elsevier - Health Sciences Division
26 April 2024

Analytical chemistry; Spectrum analysis, spectrochemistry, mass spectrometry; The environment

Sustainable Quality Improvements for Isotope Dilution in Molecular Ultratrace Analyses: Fitness for Purpose, Performance-Based Criteria, and Measurement Uncertainty uses a novel Sustainable Quality Improvement (SQI) framework with the aim of helping to re-introduce much needed flexibility and restore accountability and integrity necessary for developing confidence in products obtained with these specialty assays. The book can also be used as a comprehensive reference text for data and information on matrix-specific target analytes detection/quantitation limits, and measurement of uncertainties for planning purposes, congeners profiles, multi-phasic, multi-component and multi-analyte samples processing flow charts, and useful definitions of the underlying technology-relevant terminologies.

The SQI framework around which the book is constructed paves the way for the innovative technological solutions described in the book and is powered by three key elements: Fitness for Purpose (Data Quality Objectives), Performance-Based Measurement System (flexibility, latitude), and Measurement Uncertainty (accountability). Together, they facilitate the development and validation of advanced methodologies to resolve many of the contemporary issues associated with continuously evolving and demanding regulatory requirements. A stronger focus on effective performance feedback is demonstrated to help laboratories rethink their own approach to quality improvements.

By: Yves Tondeur (Founder and CEO It’s About Purpose LLC USA)
Imprint: Elsevier - Health Sciences Division
Country of Publication: United States
Dimensions: Height: 235mm, Width: 191mm,
Weight: 1.610kg
ISBN: 9780443290343
ISBN 10: 0443290342
Pages: 736
Publication Date: 26 April 2024
Audience: Professional and scholarly , Undergraduate
Format: Paperback
Publisher's Status: Active

Yves Tondeur is the Founder and CEO of It’s About Purpose, LLC, based in the USA. He graduated from the Free University of Brussels with a Ph.D. in Chemistry. Post-doctoral research work in the field of analytical organic mass spectrometry entailed the applications of negative chemical ionization mass spectrometry to trace analyses of chlorinated aromatic compounds, interfacing the sample preparation and mass spectrometry laboratories while developing and optimizing analytical procedures for substances of concern. He developed the original version of USEPA Method 8290 in support of the Superfund Program before rejoining a group of former scientists and colleagues who founded a commercial laboratory. He consistently and determinatively promoted the benefits of isotope dilution for measuring trace levels of toxic compounds, refined the original version of Method 8290 leading to the analytical portion of Method 23 for stack emissions, and Method 1613. During his tenure at Analytical Perspectives, efforts toward improvements in methodologies continued with a special emphasis on understanding the technology, how it differentiates itself from older methods and other technologies, and how a genuine performance-based approach could be materialized.