β-Carbolines: A Privileged Scaffold for Modern Drug Discovery

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K.L. Ameta, Ph.D. (Mody University of Science and Technology, Rajasthan, India) K.L. Ameta, Ph.D. (Mody University of Science and Technology, Rajasthan, India)

β-Carbolines

A Privileged Scaffold for Modern Drug Discovery

K.L. Ameta, Ph.D. (Mody University of Science and Technology, Rajasthan, India), K.L. Ameta, Ph.D. (Mody University of Science and Technology, Rajasthan, India)

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English

CRC Press
29 November 2024

Medical research; Pharmacology; Organic chemistry

β-Carbolines: A Privileged Scaffold for Modern Drug Discovery provides a summary of methods for the synthesis of various natural products engineered with the diverse β-carboline scaffold and their biological evaluation.

β-carboline and its derivatives have generated considerable interest in recent years for their versatile properties in chemistry and pharmacology. This is due to their ability to act as agonists to benzodiazepine receptors, hydroxy serotonin receptors, and intercalate into DNA and to inhibit CDK, topisomerase, and monoamine oxidase enzymes. Their pharmacological properties include anxiolytic, hypnotic, anticonvulsant, antiviral, antiparasitic, and antimicrobial attributes. This book provides a summary of methods for the synthesis of various natural products engineered with the diverse β-carboline scaffold and their biological evaluation.

Features:

Focuses on the different application and therapies of β-carbolines. Provides a summary of methods for the synthesis of various natural products engineered with the diverse β-carbolines. Discusses methods of biological evaluation of β-carbolines. Explores different chemical transformations occurring with synthesis using β-carbolines. Covers both heterocyclic synthesis and multicomponent synthesis related to β-carboline.

This text is key reading for researchers in medicinal chemistry and drug discovery looking to understand the broad potential of β-carbolines.

By: K.L. Ameta Ph.D. (Mody University of Science and Technology Rajasthan India), K.L. Ameta, Ph.D. (Mody University of Science and Technology, Rajasthan, India)
Imprint: CRC Press
Country of Publication: United Kingdom
Dimensions: Height: 234mm, Width: 156mm,
ISBN: 9781138482388
ISBN 10: 1138482382
Pages: 264
Publication Date: 29 November 2024
Audience: College/higher education , Further / Higher Education
Format: Hardback
Publisher's Status: Forthcoming

Prof. Keshav Lalit Ameta is working as a Professor at the Department of Applied Chemistry, School of Applied material Sciences, Central University of Gujarat, Gandhinagar, India. Prior to the current position, he has served at Sardar Patel University, Vallabh Vidyanagar, Gujarat and Mody University of Science and Technology, Lakshmangarh, Rajasthan. Prof. Ameta has published over 100 research articles in the field of organic chemistry and catalysis in the journals of international repute. He received his master and doctorate degree in Organic Chemistry from M. L. Sukhadia University, Udaipur, Rajasthan, India. He has vast experience of teaching both graduate and postgraduate level students. His research area involves synthesis, characterization and biological evaluation of different sized bioactive heterocyclic systems. In addition, to this he has keen interests in heterogeneous catalyzed organic synthesis and photocatalysis.