Dr. R. Bruce Martin is Professor Emeritus of Orthopaedic Surgery and was a member of both the Biomedical Engineering and Mechanical and Aerospace graduate groups of the University of California, Davis. Prior to his retirement, he was the Director of the Lawrence J. Ellison Musculoskeletal Research Center. He is well known for his work employing computation modeling of bone remodeling dynamics and its application to the pathogenesis of stress fractures and negative feedback systems associated with the development of osteoporosis. Dr. David Burr is a Distinguished Professor at Indiana University, holding appointments in Anatomy and Cell Biology in the School of Medicine, and in Biomedical Engineering at Indiana University-Purdue University, Indianapolis (IUPUI). He currently serves as the Associate Vice Chancellor for Research at IUPUI. Dr. Burr has been a leader in understanding the role of skeletal fatigue and mechanical adaptation of bone and cartilage. Dr. Burr isa Fellow of the American Association of Anatomists. He was presented with the Borelli Award by the American Society of Biomechanics in 2008, and was the recipient of the Henry Gray Scientific Achievement Award from the American Association of Anatomists in 2015. Dr. Neil Sharkey is a Professor of Kinesiology, with additional appointments in Orthopedics and Rehabilitation and the Huck Institutes of the Life Sciences at the Pennsylvania State University. He is currently the Vice President for Research at Penn State, having previously served as Associate Dean for Research in the College of Health and Human Development on the University Park campus. Dr. Sharkey’s research is focused on musculoskeletal biology and biomechanics, with a body of work that includes both basic science projects as well as applied studies with immediate clinical relevance. He is perhaps best known for his biomechanical models of lower extremity function in health, injury and disease. Dr. David P. Fyhrie is a Professor of Orthopaedic Surgery and Biomedical Engineering at the University of California, Davis. He is a Fellow of the American Association for the Advancement of Science and of the American Institute for Medical and Biological Engineering. He currently serves as Program Director of the Biomechanics and Mechanobiology Program for the National Science Foundation. He is known for his work applying mathematical modeling to both osteoporotic fracture prediction and adaptation of bone to load and also for experimental work on the microstructural mechanisms of bone failure.