Single-Molecule Studies of Nucleic Acids and Their Proteins

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David Bensimon (Research Director and Professor, Research Director and Professor, LPS-ENS, PSL, CNRS and Department of Chemistry and Biochemistry, UCLA, USA) Vincent Croquette (Research Director, Research Director, LPS-ENS, PSL, CNRS, France)

Single-Molecule Studies of Nucleic Acids and Their Proteins

David Bensimon (Research Director and Professor, Research Director and Professor, LPS-ENS, PSL, CNRS and Department of Chemistry and Biochemistry, UCLA, USA), Vincent Croquette (Research Director, Research Director, LPS-ENS, PSL, CNRS, France), Jean-François Allemand (Professor, Professor, LPS-ENS, PSL, CNRS, France) , Xavier Michalet (Researcher, Researcher, Department of Chemistry and Biochemistry, UCLA, USA)

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English

Oxford University Press
12 July 2018

Atomic & molecular physics; Proteins; Enzymology; Molecular biology

Series: Oxford Graduate Texts

This book provides the basis for understanding the elastic properties of nucleic acids (DNA, RNA), the methods used to manipulate them (e.g. optical, magnetic and acoustic tweezers and traps), and how to observe their interactions with proteins (e.g. fluorescence microscopy, FCS, FRET, etc.). It then exemplifies the use of these various methods in the study of three families of DNA enzymes: polymerases, helicases and topoisomerases. The book aims not to be exhaustive, but rather to stimulate the imagination of readers in the application of these single molecule approaches to the study of DNA/RNA and their interactions.

By: David Bensimon (Research Director and Professor Research Director and Professor LPS-ENS PSL CNRS and Department of Chemistry and Biochemistry UCLA USA), Vincent Croquette (Research Director, Research Director, LPS-ENS, PSL, CNRS, France), Jean-François Allemand (Professor, Professor, LPS-ENS, PSL, CNRS, France), Xavier Michalet (Researcher, Researcher, Department of Chemistry and Biochemistry, UCLA, USA), Terence Strick (Research Director and Principle Investigator, Research Director and Principle Investigator, IBENS, PSL, CNRS, France)
Imprint: Oxford University Press
Country of Publication: United Kingdom
Dimensions: Height: 249mm, Width: 178mm, Spine: 17mm
Weight: 614g
ISBN: 9780198530923
ISBN 10: 0198530927
Series: Oxford Graduate Texts
Pages: 240
Publication Date: 12 July 2018
Audience: College/higher education , Further / Higher Education
Format: Hardback
Publisher's Status: Active

David Bensimon and Vincent Croquette have been co-leaders of a group at the LPS-ENS that has been studying single DNA molecules and their interactions with proteins since 1991. Jean-François Allemand, Terence Strick and Xavier Michalet have been their students and collaborators ever since. They have jointly developed magnetic traps and have been studying various aspects of single molecule DNA/protein transactions. Since joining the lab of Professor S. Weiss at UCLA , Xavier Michalet has been focusing on the use of fluorescent and spectroscopic methods to study single biomolecules.

Reviews for Single-Molecule Studies of Nucleic Acids and Their Proteins

this book is helpful for different audiences... The volume is very well written and enjoyable to read. * Robert Ros, The Quarterly Review of Biology *