SARCOPENIA An in-depth examination of sarcopenia’s underexplored yet widespread impact within the field of gerontology
Sarcopenia is common in older men and women, and yet awareness of its clinical relevance is still relatively low. Only formally included in the International Classification of Diseases in 2016, the condition may impact societies with serious health-related and financial consequences unless consistent, effective methods of identification and management are adopted.
This second edition of Sarcopenia provides geriatricians and other healthcare professionals with a revised and expanded examination of this understudied and underdiagnosed condition. Edited by two leading authorities on the subject, it covers the epidemiology and diagnosis of sarcopenia, as well as treatment options and possible prevention strategies. Eight newly written chapters build upon existing knowledge with fresh data on topics including sarcopenia’s biomarkers and its impact on the healthcare economy. This important text:
Defines sarcopenia and explains its clinical relevance Covers all recent scientific evidence Outlines treatment options Considers prevention strategies Discusses sarcopenia as a public health priority Features eight new chapters covering topics such as sarcopenia’s clinical management, its biomarkers, and its financial impact
Containing vital information for clinicians and other professionals working in geriatric care, nursing homes, nutrition, cancer, endocrinology, surgery, sports medicine and many other specialties, Sarcopenia, second edition, is a groundbreaking and essential new resource.
List of Contributors vii Preface xiii 1 Definitions of Sarcopenia 1 Alfonso J. Cruz‐Jentoft, Beatriz Montero‐Errasquin and John E. Morley 2 Epidemiology of Muscle Mass Loss with Age 11 Marjolein Visser 3 The Role of Mitochondria in Age‐Related Sarcopenia 19 Luigi Ferrucci, Marta Zampino, Paul Coen and Bret H. Goodpaster 4 Motor Unit Remodeling 35 Ben Kirk and Mathew Piasecki 5 Nutrition, Protein Turnover and Muscle Mass 45 Stéphane Walrand, Christelle Guillet and Yves Boirie 6 Recognizing Persons at Risk for Sarcopenia 63 John E. Morley 7 Adverse Outcomes and Functional Consequences of Sarcopenia 71 Jean Woo 8 A Lifecourse Approach to Sarcopenia 77 Richard Dodds and Avan Aihie Sayer 9 Acute Sarcopenia 95 Beatrice Gasperini, Stefano Volpato and Antonio Cherubini 10 Sarcopenia, Frailty, and Intrinsic Capacity 115 Jurgen M. Bauer and Cornel Sieber 11 Osteosarcopenia 127 Ben Kirk, Jesse Zanker, Steven Phu and Gustavo Duque 12 Sarcopenic Obesity 147 Mauro Zamboni, Federica Macchi, Nicole Nori and Andrea P. Rossi 13 Sarcopenia and Cognitive Impairment 157 Liang‐Kung Chen 14 Sarcopenia and Other Chronic Organ Diseases 175 Hidenori Arai 15 Imaging of Skeletal Muscle 185 Thomas F. Lang 16 Measurements of Muscle Mass, Equations and Cut‐off Points 199 Marjolein Visser and Laura Schaap 17 Deuterated Creatine Dilution to Assess Muscle Mass (D3‐Cr Muscle Mass) in Humans: Methods, Early Results, and Future Directions 227 Peggy M. Cawthon and William J. Evans 18 Measurement of Muscle Strength and Power 239 Michael Drey, Sandra Helmers and Jürgen M. Bauer 19 Measurements of Physical Performance 253 Laura Orlandini, Yves Rolland and Matteo Cesari 20 Biomarkers for Physical Frailty and Sarcopenia: A “Two‐Body Problem” 271 Anna Picca, Riccardo Calvani and Emanuele Marzetti 21 Quality of Life and Sarcopenia 279 Charlotte Beaudart, Jean‐Yves Reginster, Olivier Bruyère and Anton Geerinck 22 Exercise Interventions to Prevent and Improve Sarcopenia 305 Mark D. Peterson and Jose A. Serra 23 Nutritional Approaches to Treat Sarcopenia 335 Tommy Cederholm, Jurgen M. Bauer and Alfonso J. Cruz‐Jentoft 24 Beta‐hydroxy‐beta‐methylbutyrate (HMB) and Sarcopenia 355 Francesco Landi, Riccardo Calvani, Anna Picca and Emanuele Marzetti 25 The Future of Drug Treatments 367 Francesco Landi, Graziano Onder and Rolland Yves 26 Sarcopenia: Is It Preventable? 403 Stany Perkisas, Keliane Liberman, Ivan Bautmans and Maurits Vandewoude 27 Financial Impact of Sarcopenia 421 Kristina Norman 28 Sarcopenia Management for Clinicians 433 Renuka Visvanathan and Solomon Yu Index 441
Alfonso J. Cruz-Jentoft, MD, Professor, Geriatrics, Universidad Europea de Madrid, and Director of Geriatric Medicine, Hospital Universitario Ramón y Cajal (IRYCIS), Madrid, Spain. John E. Morley, MD, Professor, Geriatrics, St Louis University Medical School, St Louis, MO, USA.
