Proteins: A Structural Biology Perspective

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Jia-huai Wang (Department of Medical Oncology and Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA)

Proteins

A Structural Biology Perspective

Jia-huai Wang (Department of Medical Oncology and Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA)

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English

Academic Press Inc
27 November 2024

Biophysics; Biochemistry

Proteins: A Structural Biology Perspective explains how advances in modern physics fueled the birth of structural biology and modern molecular biology in the early to mid 20th century. Scientifically rigorous and deeply informed by the author’s own 60-year career as a structural biologist, the book provides historical and personal accounts of how two generations of renowned scientists doggedly pursued their research projects to arrive at milestone achievements, while also covering basic aspects of protein structures and their evolution with a special focus on molecules at the surface of cells and viruses. Since 1962, when only a single structure for myoglobin had been determined at atomic resolution, the rapidly evolving field has grown exponentially to fill protein structure databases (PDB) worldwide with hundred thousands of structures for basic research and medical advancement. From “What is a Wave?” to “What Is Life?”, Proteins: A Structural Biology Perspective takes readers on a uniquely intimate journey through the past 100 years of protein science, while providing an up-to-the-minute assessment of successful structure prediction by AI models like AlphaFold and RoseTTAFold and where it’s all likely to lead. Outfitted with detailed illustrations and authoritative citations, this is a valuable resource for graduate students and young research scientists in biology and the medical sciences.

By: Jia-huai Wang (Department of Medical Oncology and Department of Cancer Biology Dana-Farber Cancer Institute Harvard Medical School Boston MA USA)
Imprint: Academic Press Inc
Country of Publication: United Kingdom
Dimensions: Height: 229mm, Width: 152mm,
Weight: 450g
ISBN: 9780323998932
ISBN 10: 0323998933
Pages: 378
Publication Date: 27 November 2024
Audience: Professional and scholarly , Undergraduate
Format: Paperback
Publisher's Status: Active

Jia-huai Wang is Associate professor at the Dana-Farber Cancer Institute, Harvard Medical School, USA. As a veteran structural biologist specialized in cell surface receptors functioning in immune system and nervous system he has around 140 peer-reviewed papers published, including 11 articles in Nature, Science and Cell. When in China, in the early 1970’s, he was the team member which determined the structure of insulin, one of the world’s first dozen protein structures solved. Since 1988 he has been working at Harvard. As a leading author, he has published a series of extremely important structures, such as the first virus receptor structure CD4, the first cell adhesion interacting complex CD2/CD58, the ground-breaking preTCR-ligand interacting complex and the prototypical axon guidance cue netrin-1 interactions. He has a deep understanding about protein structure and how a protein functions.