This concise and comprehensive resource is vital for the pathologist faced with providing accurate, timely, and clinically useful diagnoses for placentas, products of conception, and gravid hysterectomies. Combining the pathologic, research, and clinical expertise of a diverse group of editors and authors from centers of excellence for placental pathology, this book enables easy application of the latest Amsterdam international consensus classification criteria, with cross-references to previous terminology and a pathophysiology-based classification system. It provides complete descriptions and illustrations of diagnostic gross, microscopic, and immunohistochemical findings together with a thorough discussion of potential pitfalls and differential diagnosis. Current theories of the genetic and physiologic basis for disease processes, culminating in placental lesions are discussed. The book features high-quality images and standardized measurement tables to assist real-time diagnoses and provides access to an online version on Cambridge Core, which can be accessed via the code printed on the inside of the cover.
Part I. Introduction: 1. Normal development Mana Parast; Part II. Early Pregnancy Pathology: 2. Early pregnancy loss with normal karyotype Raymond W. Redline; 3. Early pregnancy loss with abnormal karyotype Raymond W. Redline; 4. Gestational trophoblastic disease Bradley J. Quade; Part III. Maternal Uteroplacental-Vascular Pathology: 5. Maternal vascular/trophoblastic developmental abnormalities Raymond W. Redline; 6. Distal villous hypoplasia, focal and diffuse Brendan Fitzgerald and Sarah Keating; 7. Maternal vascular malperfusion Raymond W. Redline; 8. Loss of maternal vascular integrity Drucilla J. Roberts; Part IV. Fetal Stromal-Vascular Pathology: 9. Fetal-stromal vascular developmental abnormalities Raymond W. Redline; 10. Fetal vascular malperfusion Theonia K. Boyd; 11. Loss of fetal vascular integrity Drucilla J. Roberts; Part V. Inflammatory Processes: 12. Placental infections Drucilla J. Roberts; 13. Chronic villitis/ villitis of unknown etiology (Vue) Mana Parast; 14. Chronic inflammatory lesions sometimes associated with villitis of unknown etiology (Vue) Suzanne M. Jacques and Faisal Qureshi; 15. Chronic histiocytic intervillositis Raymond W. Redline; Part VI. Other Pathologic Processes: 16. Placental size, shape, and umbilical cord abnormalities Raymond W. Redline; 17. Perivillous fibrin deposition Drucilla J. Roberts; 18. Atypical intraplacental hemorrhages/ thrombi Brendan Fitzgerald and Sarah Keating; 19. Meconium effects Theonia K. Boyd; 20. Increased circulating fetal nucleated red blood cells Theonia K. Boyd; 21. Early and late membrane/amnion rupture and amnion nodosum Suzanne M. Jacques and Faisal Qureshi; 22. Metastatic tumors Drucilla J. Roberts; 23. Heterotopias and germ cell tumors Suzanne M. Jacques and Faisal Qureshi; 24. Lysosomal storage disease, Bartter syndrome, and mimics Raymond W. Redline; Part VII. Pathology of Multiple Gestations: 25. The pathology of monochorionic placentation Monique E. De Paepe; 26. Dichorionic or higher order multiple gestations Monique E. De Paepe; Part VIII. Uteroplacental Pathology: 27. Abnormal placental location Kelly Devereaux and Ann Folkins; 28. Morbidly adherent placenta Linda M. Ernst; 29. Uterine rupture/ dehiscence Sydney Card and Ann Folkins; 30. Postpartum hemorrhage Koah Vierkoetter and Ann Folkins; Part IX. Clinicopathologic Correlations: Placental Pathology and Adverse Pregnancy Outcomes: 31. Spontaneous preterm delivery (premature labor, premature rupture of membranes, vaginal bleeding, cervical insufficiency) Raymond W. Redline; 32. Fetal growth restriction Ann Folkins; 33. Fetal death Theonia K. Boyd; 34. Central nervous system injury Raymond W. Redline; 35. Recurrent pregnancy loss Raymond W. Redline.
Raymond W. Redline is Professor of Pathology and Reproductive Biology at University Hospitals Cleveland Medical Center, where he currently directs the Pediatric, Perinatal, and Gynecologic Pathology sections. He has served for 32 years on the faculty of Harvard Medical School and Case Western Reserve University, Ohio, and chaired the Society for Pediatric Pathology Placenta Nosology Project. Theonia K. Boyd is Associate Professor of Pathology and Director of Anatomic Pathology at Boston Children's Hospital, and a staff member of the Division of Women's and Perinatal Pathology at Brigham and Women's Hospital. She served on the faculty of Tufts University School of Medicine and then Harvard Medical School, Boston, for a total of 22 years. Drucilla J. Roberts is Associate Professor of Pathology at Harvard Medical School and Associate Pathologist at Massachusetts General Hospital. She previously held a fellowship in Women's and Perinatal Pathology and a post-doctoral fellowship in the Department of Genetics at Harvard Medical School, Boston. Along with Dr Boyd, she is co-Director of a CME course on Placental Pathology.
