Pharmaceutical Formulation Development of Peptides and Proteins

Lars Hovgaard, Sven Frokjaer, Marco van de Weert

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English

CRC Press
14 October 2024

Pharmacology; Biochemistry; Pharmaceutical technology

The rapid advances in recombinant DNA technology and the increasing availability of peptides and proteins with therapeutic potential are a challenge for pharmaceutical scientists who have to formulate these compounds as drug products.

Pharmaceutical Formulation Development of Peptides and Proteins, Second Edition discusses the development of therapeutic peptides and proteins, from the production of active compounds via basic pre-formulation and formulation to the registration of the final product.

Providing integrated solutions, this book discusses:

The synthesis of peptides and the biotechnological production of proteins through recombinant DNA technology The physicochemical characteristics and stability of peptides and proteins The formulation of proteins as suspensions, solutions, and (mostly freeze-dried) solids The opportunities and challenges of non-parenteral delivery of peptides and proteins Risk factors, specifically the development of an unwanted immune response

A simulation approach to describe the fate of peptides and proteins upon administration to a biological system

The documentation required to register a protein-based drug

Scientists in the pharmaceutical industry and academia as well as postgraduate students in pharmaceutical science will find this a valuable resource.

Edited by: Lars Hovgaard, Sven Frokjaer, Marco van de Weert
Imprint: CRC Press
Country of Publication: United Kingdom
Edition: 2nd edition
Dimensions: Height: 234mm, Width: 156mm,
Weight: 725g
ISBN: 9781032920658
ISBN 10: 1032920653
Pages: 392
Publication Date: 14 October 2024
Audience: Professional and scholarly , Undergraduate
Format: Paperback
Publisher's Status: Active

Peptide Synthesis. Protein Expression. Protein Purification. Characterization of Therapeutic Peptides and Proteins. Chemical Pathways of Peptide and Protein Degradation. Physical Instability of Peptides and Proteins. Peptide and Protein Derivatives. Peptides and Proteins as Parenteral Solutions. Peptides and Proteins as Parenteral Suspensions. Rational Design of Solid Protein Formulations. Peptide and Protein Drug Delivery Systems for Nonparenteral Routes of Administration. Immunogenicity of Therapeutic Proteins. Biosimulation of Peptides and Proteins. Registration of Peptides and Proteins. Index.

Lars Rovgaard is Principal Scientist for NovoNordisk A/S and a Professor at Copenhagen University, Denmark. Sven Frokjaer is Dean of the Pharmaceutical Sciences Faculty at the University of Copenhagen Denmark. Marco van de Weert is an Associate Professor of Pharmaceutics and Analytical Chemistry at the University of Copenhagen.