Historically, sperm have been seen as simply a mechanism of transferring a haploid set of chromosomes to the oocyte. However, data from assisted reproduction therapies (ART) have demonstrated that in many couples the sperm appears to be responsible for abnormal embryogenesis. Recent advances in genetic and epigenetic techniques have identified key mechanisms by which the sperm, and the DNA carried by the sperm, can affect early embryonic development. Paternal Influences on Human Reproductive Success examines the genetic and epigenetic influences on embryogenesis, as well as practical clinical factors related to the male contribution to reproductive success. It also provides 'cutting edge' data and analysis of recent evaluations of the role of advanced paternal age, environmental influences and lifestyle factors on male reproductive fitness, making this an invaluable text for physicians treating patients for infertility, recurrent pregnancy loss, and developmental anomalies, as well as basic scientists studying embryogenesis and spermatogenesis.
Edited by:
Douglas T. Carrell Imprint: Cambridge University Press Country of Publication: United Kingdom Dimensions:
Height: 253mm,
Width: 192mm,
Spine: 15mm
Weight: 650g ISBN:9781107024489 ISBN 10: 110702448X Pages: 204 Publication Date:11 April 2013 Audience:
Professional and scholarly
,
Professional and scholarly
,
Undergraduate
,
Undergraduate
Format:Hardback Publisher's Status: Active
Douglas T. Carrell is Professor of Surgery, Obstetrics and Gynecology, and Genetics, and Director of the Andrology and IVF Laboratories, at University of Utah Health Care, Salt Lake City, Utah, USA.