Oxidative Eustress in Exercise Physiology

James N. Cobley, Gareth W. Davison

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English

CRC Press
10 June 2022

Cellular physiology; Biomechanics, human kinetics; Human biology

Series: Oxidative Stress and Disease

Oxidative Eustress in Exercise Physiology unravels key physiological responses and adaptations to different redox-regulated exercise paradigms at the cell, tissue, and whole-body level in model systems and humans in health and disease. While the mechanistic details are still unclear, key intracellular redox indices seem to be dysregulated with age. Consequently, beneficial molecular responses to acute endurance exercise decline in older individuals. Recent research suggests that manipulating mitochondrial redox homeostasis by supplementing with the mitochondria-targeted coenzyme Q10 for six weeks markedly improves physical function in older adults; i.e. it may be possible to maximise the benefits of exercise by manipulating the redox environment. The research described in this book suggests that significant translational potential exists with respect to cardiovascular disease, neurodegeneration and cancer. An international team of researchers documents the importance of redox biology in health and disease, especially when exercise is a clinically useful tool for the treatment of many diseases and conditions.

Features

Defines essential redox biology reactions and concepts in exercise physiology

Assesses key redox parameters in an in vivo human exercise context

Identifies the challenges, opportunities and boundaries of current knowledge

Includes a critique of the underlying mechanisms

Summarises examples of translationally important research relating to disease states

Related Titles

Draper, N. & H. Marshall. Exercise Physiology for Health and Sports Performance (ISBN 978-0-2737-7872-1)

Wackerhage, H., ed. Molecular Exercise Physiology: An Introduction (ISBN 978-0-4156-0788-9)

Edited by: James N. Cobley, Gareth W. Davison
Imprint: CRC Press
Country of Publication: United Kingdom
Volume: 47
Dimensions: Height: 254mm, Width: 178mm,
Weight: 880g
ISBN: 9780367508760
ISBN 10: 0367508761
Series: Oxidative Stress and Disease
Pages: 228
Publication Date: 10 June 2022
Audience: College/higher education , Professional and scholarly , Primary , Undergraduate
Format: Hardback
Publisher's Status: Active

Gareth Davison is Professor of Exercise Biochemistry and Physiology and Director of Research at the Sport and Exercise Sciences Research Institute at Ulster University in the UK. He holds a BA, MSc, and an MSt in Genomic Medicine from the University of Cambridge and was awarded his PhD in Biochemistry and Physiology in 2002. Professor Davison is a Fellow of the American College of Sports Medicine, and currently serves on several editorial boards, holding Editor roles with the Journal of Sports Sciences, Frontiers in Physiology (Redox Physiology Section) and Antioxidants. His research interests are aligned to exercise, DNA damage and antioxidant function. Recently, his laboratory has focused on bridging the gap between intracellular redox metabolism and DNA methylation in health and disease. James Cobley is a Senior Lecturer in Free Radicals at the University of the Highlands and Islands (Inverness, UK). His doctoral work, completed in 2013, focused on the redox regulation of molecular exercise adaptations in young and old human skeletal muscle. Since then, Dr Cobley has focused on developing methods to measure protein thiol redox state; which has resulted in the development of two new methods: ALISA and RedoxiFluor. Dr Cobley intends, in collaboration with others, to use both technologies to determine if and how protein thiol defined redox signalling regulates exercise adaptations and responses.