Overcoming Obstacles in Drug Discovery and Development uses real-world case studies to illustrate how critical thinking and problem solving skills are applied in the discovery and development of drugs. It also shows how developing critical thinking to overcome issues plays an essential role in the process. Modern drug discovery and development is a highly complex undertaking that requires scientific and professional expertise to be successful. After the identification of a molecular entity for treating a medical condition, challenges inevitably arise during the subsequent development to understand and characterize the biological profile; feedback from scientists is used to fine-tune the molecular entity to obtain an effective and safe product. In this process, the discovery team may identify unexpected safety issues and new medical disorders for treatment by the molecular entity. Invariably inherent in this complex undertaking are miscues, mistakes, and unexpected problems that can derail development and throw timetables into disarray, potentially leading to failure in the development of a medically useful drug. Addressing critical unexpected problems during development often requires scientists to utilize critical thinking and imaginative problem-solving skills. Overcoming Obstacles in Drug Discovery and Development will be essential to young scientists to help learn the skills to successfully face challenges, learn from mistakes, and further develop critical thinking skills. It will also be beneficial to experienced researchers who can learn from the case studies of successful and unsuccessful drug development.
Edited by:
Kan He (President of Biotranex LLC New Jersey USA),
Paul F. Hollenberg (Professor Emeritus of Pharmacology,
University of Michigan Medical School,
MI,
USA),
Larry C. Wienkers (Principal Scientist,
Wienkers Consulting,
LLC,
Bainbridge Island,
WA,
USA)
Imprint: Academic Press Inc
Country of Publication: United States
Dimensions:
Height: 276mm,
Width: 216mm,
Weight: 1.250kg
ISBN: 9780128171349
ISBN 10: 0128171340
Pages: 446
Publication Date: 24 May 2023
Audience:
Professional and scholarly
,
Undergraduate
Format: Paperback
Publisher's Status: Active
Preface Kan He, Paul Frederick Hollenberg and Larry C. Wienkers 1. Learning to think critically Brian Barnes 2. Leveraging ADME/PK information to enable knowledge-driven decisions in drug discovery and development Larry C. Wienkers 3. Systems biology and data science in research and translational medicine Karim Azer, Jeff S. Barrett, Mirjam Trame and Cynthia J. Musante 4. Drug Discovery and Development of ASO Brooke Rock 5. Drug development of covalent Inhibitors Upendra P. Dahal and Jan L. Wahlstrom 6. Denosumab: dosing and drug interaction challenges on the path to approval Graham Jang 7. Discovery and development of ADCs: obstacles and opportunities Hsuan Ping Chang, Yuen Kiu Cheung and Dhaval K. Shah 8. How to reduce risk of drug induced liver toxicity from the beginning Jinping Gan, Kan He and W. Griffith Humphreys 9. Optimization for small volume of distribution leading to the discovery of apixaban Kan He 10. Design, conduct, and interpretation of human mass balance studies and strategies for assessing metabolites-in-safety testing (MIST) in drug development Simon G. Wong and Shuguang Ma 11. Conquering low oral bioavailability issues in drug discovery and development Timothy J. Carlson 12. Case study of OATP1B DDI assessment and challenges in drug discovery and development—real-life examples Hong Shen, Jinping Gan and Giridhar S. Tirucherai 13. Investigating the link between drug metabolism and toxicity W. Griffith Humphreys 14. Overcoming nephrotoxicity in rats: the successful development and registration of the HIV-AIDS drug efavirenz (Sustiva®) D.D. Christ 15. Disproportionate drug metabolites: challenges and solutions Chandra Prakash 16. Disposition and metabolism of ozanimod—Surmounting the unanticipated challenge late in the development Deepak Dalvie and Sekhar Surapaneni 17. Application of reaction phenotyping to address pharmacokinetic variability in patient populations Robert S. Foti, Joseph M. Roesner and Joshua T. Pearson 18. Kyprolis (carfilzomib) (approved): a covalent drug with high extrahepatic clearance via peptidase cleavage and epoxide hydrolysis Zhengping Wang, Jinfu Yang an Christopher Kirk 19. Engaging diversity in research: Does your drug work in overlooked populations? Karen E. Brown and Erica L. Woodahl 20. PBPK modeling for Early clinical study decision making Arian Emami Riedmaier 21. Integrated pharmacokinetic/pharmacodynamic/efficacy analysis in oncology: importance of pharmacodynamic/efficacy relationships Harvey Wong 22. Predicting unpredictable human pharmacokinetics: Case studies from the trenches of drug discovery Zheng Yang 23. Esmolol (soft drug design) Paul W. Erhardt
Dr. Kan He holds more than 10 U.S. and international patents on new chemical entities and biotechnologies and is the author of more than 60 published scientific papers. In addition to contributing to the discovery and development of numerous successful prescription drugs currently on the market, as well as multiple preclinical and clinical development candidates, Dr. He made significant contributions to the discovery and development of the oral anticoagulant Eliquis® (Apixaban). Dr. He cofounded and currently serves as the General Manager of the innovative biotech service company Biotranex, now a wholly owned subsidiary of Frontage Laboratories, Inc. Dr. He has also held numerous scientific and managerial positions at Bristol-Myers Squib, Dupont Pharmaceuticals, and Pfizer, and cofounded and served as President of Princeton Drug Discovery Inc, Eternity Bioscience, and UniTris Biopharma. Dr. Paul Hollenberg is a Professor Emeritus of Pharmacology at the University of Michigan Medical School. He was on the faculty at Northwestern University Medical School, Wayne State University School of Medicine (Chair of Pharmacology), and then at the University of Michigan Medical School where he was Chair for more than 20 years. He cofounded Chemical Research in Toxicology in 1988 and has served as an Associate Editor and then Review Editor since that time. He was elected a Fellow of the American Chemical Society (2010), the American Association for the Advancement of Science (2012), and the American Society of Pharmacology and Therapeutics (2019). He has received several awards including the Scientific Achievement Award from the International Society for the Study of Xenobiotics in 2011 and the Founders Award from the Division of Chemical Toxicology of the American Chemical Society in 2014. He has published more than 200 peer-reviewed papers and received more than $29 million in NIH funding as a PI or Co-PI. Dr. Wienkers is currently the Principal Scientist of Wienkers Consulting, LLC. Prior to this, Larry was Vice President and Global Head of the department of Pharmacokinetics and Drug Metabolism at Amgen retiring in 2018. Before moving to Amgen, Dr. Wienkers held scientific and leadership positions in several companies (Upjohn, Pharmacia, and Pfizer) and worked across multiple drug modalities, resulting in clinical and preclinical candidates, with 30+ IND submissions and 10+ NDA submissions. He is an American Association of Pharmaceutical Scientists (AAPS) Fellow (2012), was the recipient of the University of Washington, School of Pharmacy Distinguished Alumni Award in Pharmaceutical Science and Research Award (2014), and served as Chair of American Society of Pharmacology and Experimental Therapeutics Division of Drug Metabolism (2015). In addition to consulting, he serves as an Affiliate Faculty in the Department of Medicinal Chemistry at the University of Washington and to date has published over 100 peer-reviewed manuscripts and book chapters.
