NEGLECTED TROPICAL DISEASES AND PHYTOCHEMICALS IN DRUG DISCOVERY Explore novel drug discovery updates from medicinal plants to help fight the devastating effects of neglected tropical diseases
Neglected Tropical Diseases and Phytochemicals in Drug Discovery delivers a comprehensive exploration of the drug discovery process as it pertains to neglected tropical diseases. The book covers recent advancements in drug discovery, as well as druggable targets and new challenges facing the industry. It offers readers expansive discussions of specific diseases, including protozoan, helminth, bacterial, viral, fungal, and ectoparasitic infections.
This book provides readers with insightful perspectives from leading industry voices on fifty years of trends and progress in the search for new, safe, and affordable therapeutic drugs in the fight against neglected tropical diseases. It includes information beneficial to researchers in a variety of fields of biology, chemistry, medicine, and pharmaceuticals.
The distinguished authors cover topics including the effects of phytochemicals on the causative agent of leprosy and the potential applicability of phytochemicals in the management of Dengue fever. Readers will also enjoy the inclusion of:
Thorough introductions to neglected tropical diseases, phytochemicals, protein targets, and mechanisms in drug discovery, as well as the epidemiology of neglected tropical diseases An exploration of novel bioactive lead compounds for drug discovery against neglected tropical diseases, leishmaniasis, lymphatic filariasis, trypanosomiasis, and schistosomiasis Discussions of protozoan infections, including herbal, nutritional, and traditional remedies for giardiasis and the anti-leishmanial potentials of phytochemicals Examinations of helminth infections, including the prospects of phytochemicals in the treatment of helminthiasis
Perfect for medicinal chemists, drug developers, and research and development scientists, Neglected Tropical Diseases and Phytochemicals in Drug Discovery will also earn a place in the libraries of toxicologists and researchers in biology, chemistry, medicinal chemistry, ethnobotany, and bioinformatics seeking a one-stop resource for drug discovery for neglected tropical diseases.
List of Contributors xxi Preface xxvii Part I Introduction to Neglected Tropical Diseases 1 1 Epidemiology of Neglected Tropical Diseases 3 Kurubaran Ganasegeran and Surajudeen Abiola Abdulrahman 2 Neglected Tropical Diseases, Phytochemicals, Protein Targets,and Mechanisms in Drug Discovery 37 Lalit R. Samant, Tehseen M. Dhorajiwala, and Sumit T. Haldar 3 Novel Bioactive Lead Compounds for Drug Discovery Against NeglectedTropical Diseases, Leishmaniasis, Lymphatic Filariasis, Trypanosomiasis(African Sleeping Sickness and Chagas Disease), and Schistosomiasis 75 Abeer M. El Sayed and Chukwuebuka Egbuna Part II Protozoan Infections 135 4 Herbal, Nutritional, and Traditional Remedies for Giardiasis:Phytochemicals as Drug Candidates 137 Samrat Bhattacharyya 5 Antiprotozoal Activity of Phytochemicals Against Entamoeba histolytica, the Causative Agent of Amoebiasis 171 Goutam Kumar Jena, Chinam Niranjan Patra, and Jnyanaranjan Panda 6 Antileishmanial Potentials of Phytochemicals 183 Shahira M. Ezzat, Mohamed A. Salem, and Ahmed Zayed Part III Helminth Infections 199 7 Prospects of Phytochemicals for the Treatment of Helminthiasis 201 Muhammad Akram, Charles Oluwaseun Adetunji, Ejaz Mohiuddin, Tolulope Olawumi Oladosun, Phebean Ozolua, Frances N. Olisaka, Chukwuebuka Egbuna, Olugbenga Samuel Micheal, Juliana Bunmi Adetunji, Leena Hameed, Chinaza Godswill Awuchi, Kingsley C. Patrick-Iwuanyanwu, and Olugbemi Tope Olaniyan 8 Efficacy of Phytochemicals of Medicinal Plants for the Treatment of Human Echinococcosis: Echinococcal Disease, Hydatidosis, or Hydatid Disease Drug Discovery 225 Charles Oluwaseun Adetunji, Chukwuebuka Egbuna, Tolulope Olawumi Oladosun, Muhammad Akram, Olugbenga Samuel Micheal, Frances N. Olisaka, Phebean Ozolua, Juliana Bunmi Adetunji, Goddidit Esiro Enoyoze, and Olugbemi Tope Olaniyan 9 Filaricidal Activity of Phytochemicals Against Lymphatic Filariasis 245 Jayashree V. Hanchinalmath, Darcia D’mello, Kirankumar Shivasharanappa, T. Pramod, and Sharangouda J. Patil 10 Dracunculiasis (Guinea Worm Disease) and Phytochemicals in Drug Discovery 271 Muhammad Akram, Chukwuebuka Egbuna, Mehwish Iqbal, Zarrin Basharat, Mithun Rudrapal, Kingsley C. Patrick-Iwuanyanwu, Johra Khan, and Chukwuemelie Zedech Uche 11 Medicinal Potentials of Phytochemicals as a Source of Drugs for the Treatment of Onchocerciasis (River Blindness) 283 Chandrashekar Srinivasa, Chandan Shivamallu, S. R. Santhosh Kumar, P. Sushma, Shiva Prasad Kollur, Seema J. Patel, S. S. Patil, R. Suhas, Chukwuebuka Egbuna, and Bui Thanh Tung 12 Foodborne Trematodiases and Phytochemicals 299 Shashank M. Patil, Ramith Ramu, Prithvi S. Shirahatti, and K. Sumana Part IV Bacterial Infections 337 13 Bacteriocidal Effects of Phytochemicals on Mycobacterium ulcerans, the Causative Agents of Buruli Ulcer 339 Alloysius Chibuike Ogodo, Francis Ushie Ebuara, and Chidera Favour Ogodo 14 Bactericidal Effects of Phytochemicals on Mycobacterium leprae, the Causative Agent of Leprosy 359 Chukwuebuka Egbuna, Muhammad Akram, Surajudeen Abiola Abdulrahman, Andrew G. Mtewa, Mithun Rudrapal, Kingsley C. Patrick-Iwuanyanwu, Saher Rahat, Iram Ghaffar, Amna Siddique, Jonathan Chinenye Ifemeje, Michael C. Olisah, Mihnea-Alexandru Ga˘man, Bui Thanh Tung, Chandan Shivamallu, Chukwuemelie Zedech Uche, and Johra Khan 15 Medicinal Plants and Phytochemicals Effective Against Chlamydia trachomatis, the Causative Agent of Trachoma 381 Yusuf Abubakar, Chukwuebuka Egbuna, Ahmed Olatunde, Habibu Tijjani, and Uchenna Estella Odoh 16 Yaws (Endemic Treponematoses) Drug Discovery from Phytochemicals: An Informatics Protocol for Drug Target Identification to Phytochemical Inhibitor Screening and Validation 397 Zarrin Basharat and Arisha Khoso Part V Viral Infections 417 17 Dengue Fever: A Brief Overview and Insights into the Potential Applicability of Phytochemicals in Its Management 419 Muhammad Akram, Charles Oluwaseun Adetunji, Chukwuebuka Egbuna, Shaista Jabeen, Olugbemi Tope Olaniyan, Nebechi Jane Ezeofor, Osikemekha Anthony Anani, Umme Laila, Mihnea-Alexandru Ga˘man, Kingsley C. Patrick-Iwuanyanwu, Jonathan Chinenye Ifemeje, Chukwudi Jude Chikwendu, Michael C. Olisah, and Mithun Rudrapal 18 Medicinal Potentials of Phytochemicals for the Management of Rabies 441 D. Chandan, Shiva Prasad Kollur, Shashanka K. Prasad, Chandrashekar Srinivasa, Prabhurajeshwar, S. M. Gopinath, Chukwuebuka Egbuna, and Chandan Shivamallu Part VI Fungal and Ectoparasitic Infections 453 19 Roles of Medicinal Plants in the Diagnosis and Treatment of Eumycetoma 455 Chinaza Godswill Awuchi, Muhammad Akram, and Chibueze Gospel Awuchi 20 Role of Phytochemicals in the Treatment of Ectoparasitic Infections: Scabies and Myiasis 477 Santwana Palai, Shyam Sundar Kesh, Chinaza Godswill Awuchi, Surajudeen Abiola Abdulrahman, and Chukwuebuka Egbuna Part VII Non Classified NTDs: Malaria and Human Tuberculosis 499 21 Malaria and Recent Developments in Antimalarial Drugs 501 Mithun Rudrapal and Dipak Chetia 22 Therapeutic Potentials of Phytochemicals Against Mycobacterium tuberculosis, the Causative Agent of Tuberculosis 543 Alloysius Chibuike Ogodo, Verwiyeh Silas Tatah, Francis Ushie Ebuara, and Chidera Favour Ogodo Index 571
Chukwuebuka Egbuna is a Research Biochemist in the Department of Biochemistry at Chukwuemeka Odumegwu Ojukwu University in Nigeria. He is a reviewer and editorial board member of several journals. Muhammad Akram, PhD, is Associate Professor in the Department of Eastern Medicine at the Government College University in Faisalabad, Pakistan. He has published numerous scholarly articles and is an editor and reviewer for several national and international journals. Jonathan Chinenye Ifemeje, PhD, is Professor in the Department of Biochemistry at Chukwuemeka Odumegwu Ojukwu University in Nigeria. He is Managing Editor of the Tropical Journal of Applied Natural Sciences.
