Mouse Models of Cancer

Methods and Protocols

Robert Eferl, Emilio Casanova

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English

Humana Press Inc.
31 January 2015

Oncology; Animal pathology & diseases

Series: Methods in Molecular Biology

Summary
Details

This volume is essential for geneticists, molecular biologists, biochemists, and medical doctors interested in the use of mouse models in cancer research. Recent genome studies, together with refined genetic engineering techniques, have greatly increased the value of using mice for research on cancer and other human disorders. The chapters of this book will support scientists in choosing the most suitable mouse models for their research questions. The book provides detailed methodological information for genetic or chemical induction of different types of cancer, histomorphometric cancer analysis, and in vivo imaging, as well as protocols to investigate oncogene addiction, immune surveillance, and hallmarks of cancer such as angiogenesis or metastasis. Four review-like articles provide background information on mouse technologies and histopathologic differences between mouse and human cancers. The mouse models described in individual chapters will fuel the understanding of cancer initiation, immune system roles, tumor angiogenesis, invasion, metastasis, and the relevance of molecular diversity observed among human cancers. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

Cutting-edge and resourceful, Mouse Models of Cancers: Methods and Protocols, is a valuable laboratory resource for all researchers, from the graduate level upwards, who study cancer and new possibilities for its treatment.

Edited by: Robert Eferl, Emilio Casanova
Imprint: Humana Press Inc.
Country of Publication: United States
Edition: 2015 ed.
Volume: 1267
Dimensions: Height: 254mm, Width: 178mm, Spine: 27mm
Weight: 1.443kg
ISBN: 9781493922963
ISBN 10: 1493922963
Series: Methods in Molecular Biology
Pages: 463
Publication Date: 31 January 2015
Audience: Professional and scholarly , Undergraduate
Format: Hardback
Publisher's Status: Active