Molecular Targets and Therapeutic Interventions against Neurodegenerative Diseases

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Vaishali Manikrao Patil Dileep Kumar

Molecular Targets and Therapeutic Interventions against Neurodegenerative Diseases

Vaishali Manikrao Patil, Dileep Kumar, NEERAJ MASAND

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English

CRC Press
31 March 2025

Medical research; Neurosciences; Nanotechnology; Pharmaceutical technology

This book comprehensively explores the latest advancements in the understanding, diagnosis, and treatment of neurodegenerative diseases. The chapters provide an in-depth review of current approaches and treatment strategies for Alzheimer's disease, offering insights into the latest developments and breakthroughs. It also reviews the cutting-edge research on potential novel targets for Alzheimer's pharmacotherapy, with a focus on JNK3, GSK3β, and Fyn kinase inhibitors, providing an update on related approaches and their implications. It discusses the potential of ethnomedicines as a promising tool for mitigating Alzheimer's disease, offering insights into traditional remedies and their modern applications. Additional chapters explore the influence of microglia, the neuropharmacological mechanisms associated with SARS-CoV-2, and the molecular intricacies of Parkinson’s disease. The book further covers the evolving role of artificial intelligence and machine learning in the management of neurodegenerative disorders. The chapters also examine the role of nanotechnology in addressing the challenges of diseases like multiple sclerosis. Towards the end, the book examines the role of oxidative damage in neurodegeneration and its management in related disorders. This book is an important source for neuroscientists, neurologists, and students of neuroscience.

Edited by: Vaishali Manikrao Patil, Dileep Kumar, NEERAJ MASAND
Imprint: CRC Press
Country of Publication: United Kingdom
Dimensions: Height: 254mm, Width: 178mm,
ISBN: 9781032828046
ISBN 10: 1032828048
Pages: 286
Publication Date: 31 March 2025
Audience: College/higher education , Professional and scholarly , Primary , Undergraduate
Format: Hardback
Publisher's Status: Forthcoming

Vaishali Manikaro Patil holds the position of Principal/Head at Charak School of Pharmacy, Chaudhary Charan Singh University in Meerut, India, and also serves as a Visiting Professor at the Faculty of Pharmaceutical Sciences, UCSI University in Kuala Lumpur, Malaysia. With over 17 years of academic and 3 years of industrial experience, her primary research lies in medicinal chemistry and computer-aided drug design, focusing on quantitative structure–activity relationship studies, drug-receptor interactions, and the synthesis of small heterocyclic molecules. Dr Patil, a recipient of prestigious awards, has authored numerous research papers, books, and book chapters, contributing globally through lectures and participation in scientific communities including the World Health Organization, American Chemical Society, and APTI-India. Dileep Kumar, holding degrees from Manipal University and S.G.S.I.T.S Indore, serves as an Assistant Professor at Poona College of Pharmacy and also has a visiting faculty position at the University of California, Davis. With research interests in the design of GluN2B selective NMDA receptor antagonists and amyloid-β protein aggregation inhibitors for Alzheimer's disease treatment, Dr Kumar actively contributes to cancer research at UC Davis Comprehensive Cancer Center. Neeraj Masand, Assistant Professor at Lala Lajpat Rai Memorial Medical College in Meerut, earned degrees from North Maharashtra University and Dr. A. P. J. Abdul Kalam Technical University, Lucknow. With over 16 years of academic and research experience, his current research focuses on designing gamma-secretase inhibitors for Alzheimer's disease treatment and synthesizing novel heterocyclic analogues. Dr Masand has authored numerous research papers, books, and book chapters.