Molecular Evolution on Rugged Landscapes: Protein, RNA, and the Immune System (Volume IX)

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Alan S. Perelson Stuart A. Kauffman

Molecular Evolution on Rugged Landscapes

Protein, RNA, and the Immune System (Volume IX)

Alan S. Perelson, Stuart A. Kauffman

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English

Westview Press Inc
03 July 1991

Genetics (non-medical); Animal pathology & diseases

Rugged fitness landscapes, and emerging area of biological science, underline both molecular and morphological evolution. Mathematical descriptions of such landscapes can be expected to lead to new experimental studies that actually test and establish their structure. In addition, current experimental techniques now allow one to carry out applied molecular evolution in the laboratory, opening up the possibility of evolving biomolecules for medical and industrial use.

Molecular Evolution on Rugged Fitness Landscapes,

based on a Santa Fe Institute workshop, is the first book to serve as a comprehensive introduction to these tools that permit researchers to study the structures of complex, rugged, multipeaked fitness landscapes. The first section of the book outlines a number of the general issues concerning the structure of rugged fitness landscapes. The second section examines both the history and status of experimental work on somatic mutation and the maturation of the immune response, and discusses the hypercycle model of the origin of life. This proceedings volume is an excellent reference for graduate students and professionals in immunology, population biology, physics and molecular biology.

By: Alan S. Perelson, Stuart A. Kauffman
Imprint: Westview Press Inc
Country of Publication: United States
Dimensions: Height: 229mm, Width: 152mm, Spine: 18mm
Weight: 453g
ISBN: 9780201521504
ISBN 10: 0201521504
Pages: 328
Publication Date: 03 July 1991
Audience: College/higher education , Professional and scholarly , Professional & Vocational , A / AS level , Further / Higher Education
Format: Paperback
Publisher's Status: Active

About the Santa Fe Institute -- Santa Fe Institute Editorial Board August 1989 -- Santa Fe Institute Studies in the Sciences of Complexity -- Preface: Applied Molecular Evolution on Rugged Fitness Landscapes -- Rugged Landscapes and Evolution -- Optimization on Rugged Landscapes -- A Spin-Glass Model of Evolution -- What Can Physics Do For Biology? -- Optimization of RNA Structure and Properties -- Somatic Evolution of Antibody Variable-Region Genes & Maturation of the Immune Response -- Affinity Maturation: A Retrospective View -- Maturation through Hypermutation and Selection -- Affinity Maturation on Rugged Landscapes -- Maturation of the Humoral Immune Response: A Neo-Darwinian Process? -- The NK Model of Rugged Fitness Landscapes and Its Application to Maturation of the Immune Response -- Use of Antibodies as Molecular Mimics to Probe Intermolecular Interaction Landscapes -- Affinity Maturation and Learning in Immune Networks -- Auto-Anti-ldiotype and Antigen as Selective Factors Driving B-Cell Affinity Maturation in the Immune System -- Somatic Mutation and the Antibody Repertoire: A Computational Model of Shape Space -- Applied Molecular Evolution -- Evolution of Proteins from Random Sequences: A Model for the Protein Sequence Space and an Experimental Approach -- Studies in the Evolution of Biological Activity from Random Sequences -- The Catalytic Potential of RNA -- Origin of Life Models -- Dynamics of Autocatalytic Reaction Networks

Alan S. Perelson is a Staff Member of the Theoretical Biophysics Group, and an affiliate of the centre for Nonlinear Studios, University of California, Los Alamos, National labouratory, Los Alamos, New Mexico. He received his Ph.D. in Biophysics from the University of California, Berkeley, in 1972. Perelson received the N.I.H. Research Career Development Award (1979-1984) and the Bousch Lomb Medal for Excellence in Biology. His research interests are the application of mathematics to immunological, physiological, chemical, and biophysical problems. Stuart A. Kauffman is the founding director of the Institute for Biocomplexity and Informatics and a professor of biological sciences, physics, and astronomy at the University of Calgary. He is Emeritus Professor of Biochemistry at the University of Pennsylvania, a MacArthur Fellow, and an external professor at the Santa Fe Institute. His books include The Origins of Order and At Home in the Universe: The Search for the Laws of Self-Organization and Complexity. He lives in Calgary, Canada.