Modeling the 3D Conformation of Genomes

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Guido Tiana Luca Giorgetti (Friedrich Miescher Institute for Biomedical Research, Switzerland)

Modeling the 3D Conformation of Genomes

Guido Tiana, Luca Giorgetti (Friedrich Miescher Institute for Biomedical Research, Switzerland)

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English

CRC Press
23 January 2019

Biophysics; DNA & Genome

Series: Series in Computational Biophysics

This book provides a timely summary of physical modeling approaches applied to biological datasets that describe conformational properties of chromosomes in the cell nucleus. Chapters explain how to convert raw experimental data into 3D conformations, and how to use models to better understand biophysical mechanisms that control chromosome conformation. The coverage ranges from introductory chapters to modeling aspects related to polymer physics, and data-driven models for genomic domains, the entire human genome, epigenome folding, chromosome structure and dynamics, and predicting 3D genome structure.

Edited by: Guido Tiana, Luca Giorgetti (Friedrich Miescher Institute for Biomedical Research, Switzerland)
Imprint: CRC Press
Country of Publication: United Kingdom
Dimensions: Height: 234mm, Width: 156mm,
Weight: 694g
ISBN: 9781138500792
ISBN 10: 1138500798
Series: Series in Computational Biophysics
Pages: 370
Publication Date: 23 January 2019
Audience: College/higher education , General/trade , Primary , ELT Advanced
Format: Hardback
Publisher's Status: Active

Guido Tiana, PhD, is Associate Professor of Theoretical Biophysics at the University of Milano. He obtained the PhD at the Niels Bohr Institute (Copenhagen) in 2000 and since then has worked on the physics of complex systems of biological interest, such as proteins, DNA, RNA, chromosomes and genetic networks. The methods come from the realm of statistical mechanics, making heavy use of computational tools and some experimental work. Luca Giorgetti, PhD, is a group leader at the Friedrich Miescher Institute for Biomedical Research in Basel. He obtained his PhD at the European Institute of Oncology (IEO) and University of Milan followed by a postdoctoral training at the Curie Institute in Paris. He is an expert in combining physical modeling and experimental research in chromosome conformation and transcriptional regulation.