Embryo implantation is a complex process that involves several molecular and cellular mechanisms. One of the key players in this process is microtubule polymerization, which is regulated by the microtubule-associated protein TPPP3. Microtubules are cytoskeletal structures made up of tubulin proteins that play a critical role in many cellular processes, including cell division, intracellular transport, and cell motility. In the context of embryo implantation, microtubules are essential for the proper positioning of the blastocyst (early-stage embryo) within the uterine lining, and for the subsequent invasion of the trophoblast cells into the maternal tissue. This book explores, microtubule polymerization and TPPP3 play critical roles in embryo implantation by regulating the formation of focal adhesions, promoting trophoblast invasion, and regulating the expression of implantation-related genes. Understanding the molecular mechanisms underlying these processes may lead to the development of novel therapeutic strategies for infertility and other reproductive disorders.