The occurrence of a wide variety of metal-carbon bonds in living organisms, ranging from bacteria to humans, is only recently recognized. Of course, the historical examples are the B12 coenzymes containing cobalt-carbon bonds, but now such bonds are also known for nickel, iron, copper, and other transition metal ions. There is no other comparable book; MILS-6, written by 17 experts, summarizes the most recent insights into this fascinating topic.
Edited by:
Astrid Sigel,
Helmut Sigel,
Roland K.O. Sigel
Imprint: De Gruyter
Country of Publication: Germany
Volume: 6
Dimensions:
Height: 235mm,
Width: 155mm,
Weight: 938g
ISBN: 9783110442793
ISBN 10: 3110442795
Series: Metal Ions in Life Sciences
Pages: 530
Publication Date: 20 July 2015
Recommended Age: College Graduate Student
Audience:
Professional and scholarly
,
Undergraduate
,
Undergraduate
Format: Hardback
Publisher's Status: Active
From the Content: • Organometallic Chemistry of B12 Coenzymes • Cobalamin- and Corrinoid-Dependent Enzymes • Nickel-Alkyl Bond Formation in the Active Site of Methyl-Coenzyme M Reductase • Nickel-Carbon Bonds in Acetyl-Coenzyme A Synthases/Carbon Monoxide Dehydrogenases • Structure and Function of [NiFe]-Hydrogenases • Carbon Monoxide and Cyanide Ligands in the Active Site of [FeFe]-Hydrogenases • Carbon Monoxide as Intrinsic Ligand to Iron in the Active Site of [Fe]-Hydrogenase • The Dual Role of Heme as Cofactor and Substrate in the Biosynthesis of Carbon Monoxide • Copper-Carbon Bonds in Mechanistic and Structural Probing of Proteins as well as in Situations where Copper Is a Catalytic or Receptor Site • Interaction of Cyanide with Enzymes Containing Vanadium, Manganese, Non-Heme Iron, and Zinc • The Reaction Mechanism of the Molybdenum Hydroxylase Xanthine Oxidoreductase: Evidence Against the Formation of Intermediates Having Metal-Carbon Bonds • Computational Studies of Biooganometalllic Enzymes and Cofactors
Helmut und Astrid Sigel, University of Basel, Switzerland. Roland K. O. Sigel, University of Zürich, Switzerland.