Making Sense of Genes

'A beautifully and lucidly written book of great insights ... I have not seen in one volume such clear analysis of the nuanced view of the 'gene' ... A valuable book that gives genes a new and accurate meaning and does justice to understanding genetics in a non-reductive [manner] through a systems approach. The clarity, precision and insights are wonderful.' Sheldon Krimsky, Tufts University, Massachusetts '... an extremely intellectual and erudite treatment of the history and meaning of genes and genomes. The book is half hard-core genetics and half provocative and fascinating philosophy of science ... cogently written, highly informative and genuinely thought-provoking.' John Avise, University of California '... it is really marvelous: very clearly written, very thoughtfully structured and marvellously sensitive to the needs of the reader, especially in providing 'take-home message' summaries just when and where they are most welcome. I especially admired the way the author consistently manages to help the reader dial down expectations when faced with hype about genetic tests and the latest 'gene for' discoveries.' Gregory Radick, University of Leeds 'There is a vast and curious mismatch between what biological science has discovered by empirical investigations on the mechanisms of heredity and the understanding of what appears to be the central concept, that of the gene. Despite careful attempts to show both the nature and the significance of this gap, the scientific media, and public perceptions of the concept, persistently follow a successfully popularized view that is not justified by what we now know. Kampourakis' book is an excellent attempt to correct the situation ... by bringing impressive scholastic skills to tackle the problem, the author has in my view made a very major contribution. The book deserves very wide attention.' Denis Noble, University of Oxford 'Kampourakis provides an excellent critical analysis of the genetic discourse at the intersection of science and the public, based on the latest scientific findings from genomics and systems biology. The book fills an important gap in the literature in terms of the balance it keeps between accessibility and scientific rigour. It calls for a change in the ways students and the public are told what genes are and what they do, and it does so with compelling persuasiveness. A must-read, packed with convincing empirical material, for educators, journalists and academics who are critical of the usual 'gene for' talk, but do not want to give up on the fascinating insights that the science of genetics provides.' Staffan Muller-Wille, University of Exeter '... a wonderfully engaging and pedagogical explanation of difficult concepts in biology ... Kampourakis has an incredible feeling for how to strike the balance between biological material and conceptual analysis. ... If you are teaching life sciences or engaging in any form of public outreach, this book is a must-read. ... Throughout, the material is wonderfully up to date ... this important book will help us to explain genetics to our friends, students, and fellow academics.' Tobias Uller, Frontiers in Genetics '... this book addresses the crucial educational and translational science bottlenecks of postgenomics, and delivers on its promise to the readers to move beyond the gene sequence to broader sense making for human genetics and genomics.' George P. Patrinos, OMICS: A Journal of Integrative Biology 'Kampourakis describes concisely how the late 20th century saw a revision in our view of what a gene really is. ... [He] comes down hard on the hype surrounding 'decoding the book of life', as well as [those] who did not understand the relationship between DNA sequences and complex characters. ... [the book] provides a useful companion to biology undergraduates and the interested layperson will find it informative in its critique of naive genetic determinism. I would certainly recommend it.' Charalambos P. Kyriacou, BioEssays 'Making Sense of Genes is a useful and informative refresher and reminder that, for the public, sense can be made of genes if geneticists are clear about concepts and contexts, and realistic about interpretations and implications of their research.' John R. True, The Quarterly Review of Biology 'Making Sense of Genes is an elegantly written book containing many refreshing insights about how the notion of the gene was developed in the late 19th century and how it is used and misused today. ... Rather than depending on facile metaphors for gene function ('blueprints', 'programs') like most other popular treatments of biology, the author, Kostas Kampourakis, deftly deconstructs them, showing why they have been adopted, but how they mislead. He convincingly shows that while the notion that there are genes 'for' specific characters, such as height or aggressive behavior, is based on multiple misconceptions, the idea of genes 'for' some diseases, including metabolic disorders and cancers, may have some merit, even though strict causation is rarely straightforward.' Stuart Newman, GeneWatch 'Kampourakis's Making Sense of Genes ... [offers] a clear and compelling account of what genes do and do not actually do. It is one of the most readable accounts of genetics that also gives careful attention to those complex historical-philosophical frameworks that are so often left out of discussions written by scientists. ... [This] is a text suitable for students and secondary educators, certainly. But, more than this, it is a text for researchers to digest. Perhaps it will help experts in genetics to see the gaps in their ability to convey philosophical and historical information to students and the general public that leads to so many misunderstandings ... Kampourakis is to be applauded for writing such a clear and persuasive text encouraging us to reframe our understanding and misunderstanding of the science, its history, and its implications for our daily lives.' Erik L. Peterson, Metascience 'A beautifully and lucidly written book of great insights ... I have not seen in one volume such clear analysis of the nuanced view of the 'gene' ... A valuable book that gives genes a new and accurate meaning and does justice to understanding genetics in a non-reductive [manner] through a systems approach. The clarity, precision and insights are wonderful.' Sheldon Krimsky, Tufts University, Massachusetts '... an extremely intellectual and erudite treatment of the history and meaning of genes and genomes. The book is half hard-core genetics and half provocative and fascinating philosophy of science ... cogently written, highly informative and genuinely thought-provoking.' John Avise, University of California '... it is really marvelous: very clearly written, very thoughtfully structured and marvellously sensitive to the needs of the reader, especially in providing 'take-home message' summaries just when and where they are most welcome. I especially admired the way the author consistently manages to help the reader dial down expectations when faced with hype about genetic tests and the latest 'gene for' discoveries.' Gregory Radick, University of Leeds 'There is a vast and curious mismatch between what biological science has discovered by empirical investigations on the mechanisms of heredity and the understanding of what appears to be the central concept, that of the gene. Despite careful attempts to show both the nature and the significance of this gap, the scientific media, and public perceptions of the concept, persistently follow a successfully popularized view that is not justified by what we now know. Kampourakis' book is an excellent attempt to correct the situation ... by bringing impressive scholastic skills to tackle the problem, the author has in my view made a very major contribution. The book deserves very wide attention.' Denis Noble, University of Oxford 'Kampourakis provides an excellent critical analysis of the genetic discourse at the intersection of science and the public, based on the latest scientific findings from genomics and systems biology. The book fills an important gap in the literature in terms of the balance it keeps between accessibility and scientific rigour. It calls for a change in the ways students and the public are told what genes are and what they do, and it does so with compelling persuasiveness. A must-read, packed with convincing empirical material, for educators, journalists and academics who are critical of the usual 'gene for' talk, but do not want to give up on the fascinating insights that the science of genetics provides.' Staffan Muller-Wille, University of Exeter '... a wonderfully engaging and pedagogical explanation of difficult concepts in biology ... Kampourakis has an incredible feeling for how to strike the balance between biological material and conceptual analysis. ... If you are teaching life sciences or engaging in any form of public outreach, this book is a must-read. ... Throughout, the material is wonderfully up to date ... this important book will help us to explain genetics to our friends, students, and fellow academics.' Tobias Uller, Frontiers in Genetics '... this book addresses the crucial educational and translational science bottlenecks of postgenomics, and delivers on its promise to the readers to move beyond the gene sequence to broader sense making for human genetics and genomics.' George P. Patrinos, OMICS: A Journal of Integrative Biology 'Kampourakis describes concisely how the late 20th century saw a revision in our view of what a gene really is. ... [He] comes down hard on the hype surrounding 'decoding the book of life', as well as [those] who did not understand the relationship between DNA sequences and complex characters. ... [the book] provides a useful companion to biology undergraduates and the interested layperson will find it informative in its critique of naive genetic determinism. I would certainly recommend it.' Charalambos P. Kyriacou, BioEssays 'Making Sense of Genes is a useful and informative refresher and reminder that, for the public, sense can be made of genes if geneticists are clear about concepts and contexts, and realistic about interpretations and implications of their research.' John R. True, The Quarterly Review of Biology 'Making Sense of Genes is an elegantly written book containing many refreshing insights about how the notion of the gene was developed in the late 19th century and how it is used and misused today. ... Rather than depending on facile metaphors for gene function ('blueprints', 'programs') like most other popular treatments of biology, the author, Kostas Kampourakis, deftly deconstructs them, showing why they have been adopted, but how they mislead. He convincingly shows that while the notion that there are genes 'for' specific characters, such as height or aggressive behavior, is based on multiple misconceptions, the idea of genes 'for' some diseases, including metabolic disorders and cancers, may have some merit, even though strict causation is rarely straightforward.' Stuart Newman, GeneWatch 'Kampourakis's Making Sense of Genes ... [offers] a clear and compelling account of what genes do and do not actually do. It is one of the most readable accounts of genetics that also gives careful attention to those complex historical-philosophical frameworks that are so often left out of discussions written by scientists. ... [This] is a text suitable for students and secondary educators, certainly. But, more than this, it is a text for researchers to digest. Perhaps it will help experts in genetics to see the gaps in their ability to convey philosophical and historical information to students and the general public that leads to so many misunderstandings ... Kampourakis is to be applauded for writing such a clear and persuasive text encouraging us to reframe our understanding and misunderstanding of the science, its history, and its implications for our daily lives.' Erik L. Peterson, Metascience