Since the development of the first clinical MRI contrast agent, Gd(DTPA) (or Magnevist®) in the early 1980s, another three linear and three macrocyclic (eg. Gd(DOTA) (Dotarem®) have been introduced in the clinic and inspired a huge number of researchers worldwide to perform preclinical research to obtain contrast agents for many kinds of clinical applications, which are described in this book. The most current research has been assembled here and can be used by the scientific community to continue increasing the relevance of metal-containing molecules and nanomaterials for MRI-based diagnosis and thus increase the practical use of these systems.
Presents the importance of metal-containing molecules and nanomaterials for MRI-based diagnosis and the practical use of these systems. Discusses the structure and dynamics of Ln-based contrast agents as well as computational studies related to these agents. Endorses and stimulates research in the vibrant field of biological inorganic chemistry. Reviews the most current research supporting the relevance of metal-containing molecules and nanomaterials for diagnosis and therapy. The authors are preeminent bioinorganic and medicinal inorganic chemists and review the most current research in this field.
Edited by:
Carlos F.G.C. Geraldes (University of Coimbra Portugal)
Imprint: CRC Press
Country of Publication: United Kingdom
Dimensions:
Height: 229mm,
Width: 152mm,
Weight: 453g
ISBN: 9781032438368
ISBN 10: 1032438363
Series: Metal Ions in Life Sciences Series
Pages: 410
Publication Date: 21 August 2024
Audience:
College/higher education
,
Professional and scholarly
,
Primary
,
Undergraduate
Format: Hardback
Publisher's Status: Forthcoming
Chapter 1 Synthesis and Characterization of Ligands and Their Gd(III) Complexes Raphaël Tripier, Maryline Beyler Chapter 2 PARASHIFT Systems: Including 19F Effects Peter Harvey Chapter 3 Targeted MRI Contrast Agents Alexander G. Sertage, Md. Sydul Islam, and Matthew J. Allen Chapter 4 Responsive MRI Contrast Agents Luke A. Marchetti, Manon Isaac, Célia S. Bonnet Chapter 5 Mn-Based Small Complexes as MRI Contrast Agents Zoltán Garda, Sara Lacerda and Éva Tóth Chapter 6 Other First-Row Transition Metal-Based Complexes as MRI Contrast Agents Janet R. Morrow and Jaclyn J. Raymond Chapter 7 Lanthanide-based paramagnetic chemical exchange saturation transfer (paraCEST) agents for MRI A. Dean Sherry & Mark Woods Chapter 8 LipoCEST and Similar Systems Silvio Aime and Enzo Terreno Chapter 9 Superparamagnetic Iron Oxide and Ferrite Nanoparticles for MRI Thomas Vangijzegem, Levy Van Leuven, Dimitri Stanicki, Robert N. Muller, Sophie Laurent Chapter 10 Ln-based particles as MRI contrast agents Joop A. Peters and Kristina Djanashvili Chapter 11 Manganese and Iron Based Nanoparticles as MRI Contrast Agents Fabio Carniato, Lorenzo Tei, and Carlos F,G. C. Geraldes Chapter 12 Advances in PET/MRI and Probe Development for Biomedical Precision Imaging Applications Jan Kretschmer, Juan Pellico, Angelina Prytula-Kurkunova, Rafael Torres Martin De Rosales, Andre Ferreira Martins
Carlos F. G. C. Geraldes received his “Licenciatura” (MS equivalent) in Chemistry from the University of Coimbra in 1972, and his Doctor of Philosophy (D.Phil) degree in Inorganic Chemistry from the University of Oxford in 1976 with Prof. Robert J. P. Williams. In his graduate work, he studied the solution conformation of a series of mono and dinucleotides using the so-called Lanthanide Probe Method, measuring the proton NMR induced shifts and nuclear relaxation rates of their complexes of whole paramagnetic Ln(III) series combined with coupling constants and NOE data.
