Landmark Papers in Pain

Section 1: Historical 1: JAW (Tony) Wildsmith: Local anaesthetic substitutes for cocaine 2: Ben M. Thomas: Innovative concepts in pain management 3: Sebastian Brandner and Brigitta Brandner: Explaining reflex sympathetic dystrophy 4: Alain Eschalier and Christophe Mallet: The rediscovery of paracetamol 5: Fabrizio Benedetti: The pharmacology of placebos 6: Jean-Sebastien Walczak: Understanding the responsiveness of c-fibres 7: Tony Dickenson: A new theory of pain 8: Manon Choiniere and Gabriella Page: Three determinants of pain 9: Guy Rousseau: Purinergic nerves: a new type of nerve 10: Jeffrey S. Mogil: Genetic differences in opiate receptors 11: Pierre Rainville: Endogenous opioids in placebo-induced analgesia 12: Eric Troncy: Ethical pain experimentation in conscious animals 13: Argyro Fassoulaki: Local anaesthetic creams 14: Cathy Price: The backpain revolution 15: Pierre Sirois and Pedro D'orleans-Juste: The mechanism of aspirin 16: Yasser Al Omran and Qasim Aziz: Mechanisms of visceral pain in IBS 17: Philippe Richebe and Cyril Rivat: The effects of morphine on the central nervous system 18: Joan Hester: Opiods in palliative care 19: Tony Dickenson: Endogenous opioids in the central nervous system 20: Craig W. Steven: Spinal opioid analgesia in the rat Section 2: Firsts 21: Paul Farquhar-Smith: The key role of NGF in inflammatory pain processing 22: Elizabeth J. Bradbury and Nicholas D. James: Mapping of neurotrophin receptors on adult sensory neurons 23: Stephen R. Humble: Plasticity in somatic receptive fields after nerve injury 24: Amanda Klein and Matthias Ringkamp: Peripheral neural mechanisms of cutaneous hyperalgesia and heat pain 25: Mary E. Abood and Thomas Gamage: The Cloning and Characterization of CB1 26: Mark F. Bird and David Lambert: Deorphanisation of ORL-1/LC132 by reverse pharmacology in two landmark studies 27: Istvan Nagy: The capsaicin receptor 28: Istvan Nagy: Vanilloid receptor 1 in inflammatory thermal hyperalgesia 29: Pierre Rainville: A signature of pain in the brain 30: John Schutzer-Weissmann: Cytokines as central to peripheral sensitisation and hyperalgesia 31: Claudia Sommer: Endogenous opioids mediate stress-induced analgesia 32: Ke Ren Ronald Dubner: The first crystal structure of an iGluR ligand-binding core 33: Andrea Hohmann: Control of pain initiation by endogenous cannabinoids 34: Julie Desroches: Peripheral Analgesia involves Cannabinoid Receptors 35: Marzia Malcangio: Glia: a new pain target 36: Bradley Kerr and Muhammad Saad Yousuf: The challenges of animal models of pain 37: Philippe Sarret: Mechanisms of bone cancer pain 38: Roger Knaggs: Molecular Structure of the Mu-Opioid Receptor 39: Serge Marchand: Milestone Effect of DNIC in our Understanding of Pain 40: Sheila Black: Original description of central sensitisation 41: Lesley Bromley: Molecular basis for Placebo effect Section 3: Science 42: Robert D. Searle: Early discussions on a mechanistic approach to pain 43: Alfredo Ribeiro and Da Silva Claire Magnussen: Plasticity: a key concept in pain 44: Enrique Collantes: The importance of descending modulatory pain systems 45: Helen Laycock: Nocebo and its importance in clinical practice 46: Pierre Beaulieu: Mechanisms of Action of Acetaminophen for Pain Treatment 47: Juergen Sandkuehler: Making the link from central sensitization to clinical pain Section 4: Clinical 48: Vicky Tidman: Proof of concept: epidural morphine 49: Mike Shipley: The Definition of Fibromyalgia 50: Suzanne Chapman: The advent of PCA for post operative analgesia 51: Matthew J. Allsop and Michael Bennett: Undertreatment of pain with metastatic cancer 52: Alison Bliss: Faces scales in paediatric pain assessment 53: Stephan Schug: Epidural block and phantom limb pain 54: Giovambattista Zeppetella: Clarifying the concept of Breakthrough pain Section 5: Mechanisms 55: Alison Bliss: Paediatric pain epidemiology 56: Peter Kamerman: Recognising the importance of HIV disease and pain 57: Andrew N. Davies: Fast acting fentanyl for breakthrough pain 58: Paul Farquhar-Smith: The additive analgesia of adrenaline in epidural blockade 59: Felicia Cox: What is the clinical relevance of the Likert scale for pain 60: Jane Quinlan: Post operative pain: assessing the standards 61: Kirsty Bannister: Opioid induced hyperalgesia 62: Naomi Scott: CRPS epidemiology 63: Paul Farquhar-Smith: Seminal paper on epidemiology of cancer pain 64: Arun Bhaskar: Endoscopic ultrasound guided coeliac plexus block Section 6: Neuropathic 65: Nicholas D. James and Elizabeth J. Bradbury: Autotomy: an early neuropathic pain model 66: Tudor Phillips: Risk factors for post amputation pain 67: Matthew Brown: Chronic constriction injury (CCI) model of neuropathic pain 68: Mick G. Serpell: Antineuropathic medication combination therapy 69: Rajesh Gupta: RCT evidence for gabapentin in post herpetic neuralgia 70: Turo J. Nurmikko: Identification of the target of gabapentinoid action in neuropathic pain 71: Matthew Brown: Recognition of the importance of Neuropathic pain epidemiology 72: Abdelghani Mowafak: Botox analgesia for neuropathic pain 73: Sibtain Anwar: DNIC and prediction of chronic post surgical pain 74: Richard M. Langford: Pregabalin in the reduction of chronic post knee surgery chronic pain 75: Toby Newton John: Multidisciplinary Cognitive Behavioural Treatment for Chronic Pain 76: Rakesh Jain: Disability in Chronic Low Back Pain Section 7: Psychosocial 77: Amanda Williams: The Understanding of Social Effects in Pain Section 8: Genetics 78: Bhagat Singh. Alban Latremoliere, and Michael Costigan: Congenital insensitivity to pain 79: Ingolf Cascorbi: Polymorphic CYP2D6 as the Responsible Enzyme of Activation 80: Matthew Hamilton: COMT genotypes in pain responses 81: Bradley J. Kerr: The link between NaV1.7 mutation and erythromelalgia 82: Fausto Morell-Ducos: COMT and morphine use in cancer pain 83: Roman Cregg and Biloshytsky Vadym: Pioneering use of gene therapy for pain