Ion channels are intimately involved in the everyday physiological functions that enable us to live a full and varied life. When disease strikes, malfunction of ion channels or their dependent processes is often involved, either as the cause or effect of the illness. Thus, billions of dollars have been, and still are being, invested in research to understand the physiological and pathophysiological functions of ion channels in an attempt to develop novel therapeutic treatments for a wide range of diseases. This book provides a comprehensive overview of ion channel structure and function. It comprises two major parts: Part one - an introductory overview of the ion channel superfamily and the generic aspects of ion channel function. This part also reviews the methodologies by which ion channel function can be studied from the perspective of performing detailed biophysical characterisation through to the deployment of high throughput approaches for identifying novel ion channel ligands. Part two of the book provides an in-depth review of the individual ion channel subfamilies and, as such, is subdivided into four broad sections:
Voltage-Gated Ion Channels, Extracellular Ligand-Gated Ion Channels, Intracellular Ligand-Gated Ion Channels, and Polymodal-Gated Ion Channels, with each chapter therein focused on specific family members. These chapters have been written by world leading experts and provide a detailed overview of the structure, biophysics, localization, pharmacology, physiology, and disease relevance of each particular ion channel subfamily.
Reviewing both the basic principles of ion channel function and providing a detailed up-to-date review of the physiological and pharmacological aspects of individual ion channel sub-families, this book constitutes both an excellent introduction to the field for non-specialists as well as a highly valuable reference text for experienced researchers already working in the ion channel area.
Edited by:
James Kew (Director Molecular and Cellular Biology Schizophrenia & Cognitive Disorders Discovery Performance Unit Neurosciences CEDD GlaxoSmithKline New Frontiers Science Park Harlow U.K.),
Ceri Davies (,
Mood and Anxiety Doisorders Discovery Performance Unit,
Neurosciences CEDD,
GlaxoSmithKline,
Medicines Research Center,
Via A Fleming,
Verona,
Italy)
Imprint: Oxford University Press
Country of Publication: United Kingdom
Dimensions:
Height: 284mm,
Width: 227mm,
Spine: 28mm
Weight: 1.733kg
ISBN: 9780199296750
ISBN 10: 0199296758
Pages: 576
Publication Date: 24 September 2009
Audience:
College/higher education
,
Professional and scholarly
,
Further / Higher Education
,
Undergraduate
Format: Hardback
Publisher's Status: Active
Introduction 1: Derek Tresize, Tim Dale and Martin Main: Introduction to Ion Channel Structure and Function Voltage Gated Ion Channels 2.1: Bernardo Rudy: Voltage-Gated K+ channels 2.2: Bernardo Rudy, Jonathon Maffie, Yimy Amarillo, Brian Clark, Hyo-Young Jeong, Illya Kruglikov, Elaine Kwon, Marcela Nadal and Edward Zagha: Kv1-Kv6 \ Kv8-Kv9 family 2.3: Jonathan Robbins and Gayle Passmore: Kv7 family 2.4: Matthew Perry and Michael Sanguinetti: Kv10-Kv12 families 2.5: Dawon Kang and Donghee Kim: K2P families 2.6: Joel Baumgart and Edward Perez-Reyes: Voltage-Gated Ca2+ Channels 2.7: Sulayman Dib-Hajj and Tony Priestley: Voltage-Gated Na+ Channels 2.8: Michael Pusch: Voltage-Gated Chloride Channels 2.9: Mira Kuisle and Anita Lüthi: Hyperpolarization-Activated Channels Extracellular Ligand-Gated Ion Channels 3.1: Cys Loop Receptors 3.2: Marzia Lecchi, Jean-Charles Hoda, Ronald Hogg and Daniel Bertrand: Nicotinic Acetylcholine Receptors 3.3: John Peters, Michelle Cooper, Matthew Livesey, Jane Carland and Jeremy Lambert: 5-HT3 receptors 3.4: Carmen Villmann and Cord-Michael Becker: Glycine Receptors 3.5: Hans Möhler, Dietmar Benke Uwe Rudolph and Jean-Marc Fritschy: GABAA receptors 3.6: Glutamate Receptors 3.7: Laura Jane King, Hilary Jackson, Thomas Chater, Peter Hastie and Jeremy Henley: AMPA Receptors 3.8: Sanja Selak, Rocio Rivera, Ana Paternain and Juan Lerma: Kainate Receptors 3.9: Alasdair Gibb: NMDA Receptors 3.10: ATP Receptors 3.11: Iain Chessell and Anton Michel: P2X Receptors 3.12: Others 3.13: Eric Lingueglia and Michel Lazdunski: Acid Sensing Ion Channels (ASICs) 3.14: Stephan Kellenberger and Laurent Schild: Epithelial Sodium Channels Intracellular Ligand-Gated Ion Channels 4.1: Jorge Arreola, Juan Pablo Reyes, Teresa Rosales-Saavedra and Patricia Pérez-Cornejo: Chloride Channels Activated by Intracellular Ligands 4.2: Zhengchao Wang and Fangxiong Shi: Cyclic Nucleotide-Gated Cation Channels 4.3: Morten Grunnet, Dorte Strøbæk, Søren-Peter Olesen and Palle Christophersen: KCa1- KCa5 Families 4.4: KIR family 4.5: Hiroshi Hibino and Yoshihisa Kurachi: KIR1,2,4,5,7 families 4.6: Atsushi Inanobe and Yoshihisa Kurachi: KIR3 family 4.7: Christophe Moreau, Andre Terzic and Michel Vivaudou: KIR6 (KATP) family 4.8: Stephan Lehnart and Andrew Marks: Ryanodine Receptors 4.9: Randen Patterson: IP3 receptor Polymodal Gated Ion Channels 5.1: Grzegorz Owsianik, Thomas Voets and Bernd Nilius: Transient Receptor Potential Channels 5.2: Elizabeth Hartfield, Annette Weil, James Uney and Eric Southam: Connexins - Gap Junctions
James Kew received a degree in Biological Sciences from Exeter University in 1991 and a Ph.D. from Cambridge University in 1995. He joined F.Hoffmann-La Roche in Basel in 1995, first as a postdoctoral scientist and subsequently as head of an electrophysiology and cell biology laboratory. During this period his work focussed on the pharmacology, physiology/pathophysiology and therapeutic potential of both ionotropic and metabotropic glutamate receptors and their ligands. He joined GlaxoSmithKline in 1995 as Head of Electrophysiology in the Psychiatry CEDD before moving to head the newly formed Psychiatry Discovery Technology Group in October 2006. Since October 2008 he has led the Molecular and Cellular Biology group within the Schizophrenia and Cognitive Disorders Discovery Performance Unit in the Neurosciences CEDD. Ceri Davies received BSc (Hons) and Ph.D. degrees in Pharmacology from Bristol University in 1988 and 1991. He held a Lectureship in Neuropharmacology at the University of Edinburgh until 1998 when he moved into the pharmaceutical industry running an electrophysiology team at Organon laboratories near Glasgow. During this appointment his work focussed on developing novel approaches to treat psychiatric disorders. He joined GlaxoSmithKline a year later as Head of Electrophysiology in the Neurology and Gastrointestinal Centre for Excellence in Drug Discovery (CEDD) before moving to head up the Neuropharmacology and Physiology department in the Psychiatry CEDD in 2003. Since May 2008 he has led the Synaptic Plasticity and Neural Networks Discovery Performance Unit within the newly formed Neurosciences CEDD.
