This collection features four peer-reviewed reviews on African swine fever.
The first chapter reviews recent research on the causes and epidemiology of African swine fever (ASF). It discusses the causative agent for ASF, its origins in Africa and its subsequent spread into other regions of the world. The chapter focusses on the distribution of genotype I and II strains of ASF and summarises the clinical indicators of the disease, as well as the different cycles involved in transmission and their dynamics.
The second chapter provides an overview of established practices relating to the types and preparation of samples for analysis, as well as current diagnostic tools. The chapter also considers the emergence of diagnostic techniques which go beyond those already established, including the use of alternative sample matrices, pen-side diagnostics and genomic epidemiology.
The third chapter highlights the surveillance tools currently available for the early detection of the presence of ASF, focussing on the use of clinical, serological and virological surveillance methods. The chapter also reviews the biosecurity measures which can be implemented to prevent its spread, including adequate cleaning and disinfection procedures.
The final chapter discusses recent advances in developing a vaccine for ASF in light of the recent outbreaks which have resulted in the culling of millions of pigs, both domestic and wild. The chapter also highlights current disease management practices used to control and limit outbreaks of the disease.
Chapter 1 - Advances in understanding the characteristics and epidemiology of African swine fever: Youming Wang, China Animal Health and Epidemiology Centre (CAHEC), China; 1 Etiology2 Distribution3 Clinical signs and postmortem findings4 Disease transmission5 Transmission dynamics6 References Chapter 2 - Advances in surveillance and diagnostic techniques for tracking the spread of African swine: Sandra Blome, Friedrich Loeffler Institute, Germany Chapter 3 - Risk-based measures for prevention and control of African swine fever (ASF) in pigs: Silvia Bellini, IZSLER, Italy; 1 Introduction2 Surveillance measures3 Biosecurity measures4 Cleaning and disinfection measures5 Conclusion6 Where to look for further information7 References Chapter 4 - Advances in finding a vaccine for African swine fever: Douglas Gladue and Manuel V. Borca, USDA-ARS, USA; 1 ASFV proteins inducing protective immunity and the development of subunit vaccines2 Live attenuated Vaccines- Attenuated field isolates3 Live attenuated Vaccines -Adaptation to cell culture to decrease virulence4 Live attenuated Vaccines- Initial identification of genetic determinants of virulence in ASFV5 Case Study: Development of a ASFV Vaccine to the new emerging strain ASFV Georgia6 Other advances in ASFV discovery of determinants of virulence7 Summary8 Future trends in research9 Where to look for further information10 References
