HOFFBRAND’S ESSENTIAL HAEMATOLOGY The Essentials is an international, best-selling series of textbooks, all of which are designed to support lecture series or themes on core topics within the health sciences. See www.wiley.com for further details.
The definitive introductory textbook on haematology, covering basic science, diagnostic testing, clinical features, and patient management
Hoffbrand’s Essential Haematology has helped medical students and trainee physicians understand the core principles of clinical and laboratory haematology for more than four decades. Original contributions by leading experts provide authoritative coverage of clinical and laboratory features and management within haematology, including the haematological aspects of systemic diseases, pregnancy, and the neonate. Hundreds of high-quality colour images illustrate various anaemias and white cell disorders, leukaemias, lymphomas and myeloma, bleeding and thrombotic disorders, and other blood diseases.
Now in its ninth edition, this classic textbook incorporates current knowledge of the pathogenesis of blood diseases, the 5th WHO (2022) classification of haematological neoplasms, the detection of minimal residual disease, advances in the treatment of benign and neoplastic blood diseases. New sections focus on the haematological consequences of COVID-19 infection and vaccine -induced immune thrombotic thrombocy-topenia (VITT). Additional and expanded chapters describe non-Hodgkin lymphomas, amyloid, and haemophilia.
Supported by a companion website with hundreds of MCQs and PowerPoint slides, Hoffbrand’s Essential Haematology, Ninth Edition, remains an indispensable resource for trainee haematologists and physicians.
Preface to the Ninth Edition iv About the Companion Website v 1 Haemopoiesis 1 2 Erythropoiesis and general aspects of anaemia 11 3 Hypochromic anaemias 27 4 Iron overload 42 5 Megaloblastic anaemias and other macrocytic anaemias 50 6 Haemolytic anaemias 65 7 Genetic disorders of haemoglobin 79 8 The white cells, part 1: granulocytes, monocytes and their benign disorders 99 9 The white cells, part 2: lymphocytes and their benign disorders 116 10 The spleen 131 11 The aetiology and genetics of haematological neoplasia 138 12 Management of haematological malignancy 155 13 Acute myeloid leukaemia 168 14 Chronic myeloid leukaemia 185 15 Myeloproliferative neoplasms 194 16 Myelodysplastic neoplasms 210 17 Acute lymphoblastic leukaemia 222 18 The chronic lymphocytic leukaemias 236 19 Hodgkin lymphoma 246 20 Non-Hodgkin lymphomas 1: General aspects 259 21 Non-Hodgkin lymphomas 2: Individual diseases 270 22 Multiple myeloma and related plasma cell neoplasms 287 23 Amyloid 302 24 Aplastic anaemia and bone marrow failure syndromes 309 25 Haemopoietic stem cell transplantation 320 26 Platelets, coagulation and normal haemostasis 337 27 Bleeding disorders caused by platelet and vascular abnormalities 355 28 Hereditary coagulation disorders 370 29 Acquired coagulation disorders and thrombotic microangiopathies 385 30 Thrombosis 1: Pathogenesis and diagnosis 399 31 Thrombosis 2: Treatment 417 32 Haematological changes in systemic diseases 437 33 Blood transfusion 451 34 Pregnancy and neonatal haematology 465 Appendix: 5th edition (2022) of the World Health Organization Classification of Haematolymphoid Tumours 475 Index 478
A. VICTOR HOFFBRAND, Emeritus Professor of Haematology, University College London, UK. CONTRIBUTING AUTHORS PRATIMA CHOWDARY, Professor of Haemophillia and Haemostasis, University College London; Consultant Haematologist, KD Haemophilia and Thrombosis Centre, Royal Free Hospital, London. GRAHAM COLLINS, Associate Professor of Haematology and Consultant Haematologist, Oxford Cancer and Haematology Centre, Oxford, UK. JUSTIN LOKE, AACR-CRUK Transatlantic Fellow, Dana-Farber Cancer Institute, Boston, USA and University of Birmingham, Birmingham, UK.
