A. VICTOR HOFFBRAND, Emeritus Professor of Haematology, University College London, UK. CONTRIBUTING AUTHORS PRATIMA CHOWDARY, Professor of Haemophillia and Haemostasis, University College London; Consultant Haematologist, KD Haemophilia and Thrombosis Centre, Royal Free Hospital, London. GRAHAM COLLINS, Associate Professor of Haematology and Consultant Haematologist, Oxford Cancer and Haematology Centre, Oxford, UK. JUSTIN LOKE, AACR-CRUK Transatlantic Fellow, Dana-Farber Cancer Institute, Boston, USA and University of Birmingham, Birmingham, UK.