• Hepatocellular carcinoma (HCC) used to be regarded as a rare disease. However, the increasing numbers of chronic HCC carriers in the U.S. and subsequent increased incidences of HCC seen in most large medical centers means that it is no longer an uncommon disease for gastroenterologists or oncologists to encounter and its incidence and epidemiology are changing. During this exciting time in the field of HCC basic science and clinical management, many changes are simultaneously occurring at multiple levels of our understanding and management of the disease. Suddenly, there are several new choices of therapy to offer patients. Hepatocellular Carcinoma, 3rd edition addresses this fast-changing disease and gives the reader a clearer understanding of the many mechanisms involved in carcinogenesis of the liver. This comprehensive and detailed review of how to diagnose and treat hepatocellular carcinoma is written by international leaders in the field, covering both clinical treatment choices and the basic science underlying HCC development. Updated and enhanced from the last edition in 2009, Hepatocellular Carcinoma, 3rd edition features 12 new chapters including discussion of molecular markers, molecular hepatocarcinogenesis, microenvironment, heterogeneity, the new and exciting contributions of immunotherapy, and updates on the major effective hepatitis therapies that will transform HCC incidence and perhaps also the therapy. This cutting-edge text is a vital resource and must-have for today’s hepatologists and medical and surgical oncologists.
""This is a well written text and should be a good reference book for those who see patients with HCC.."" - Practical Gastroenterology
""...a useful tool for both physicians and surgeons with a specific interest in the management of patients with HCC."" - Digestive and Liver Disease
Edited by:
Brian I. Carr
Imprint: Springer International Publishing AG
Country of Publication: Switzerland
Edition: Softcover reprint of the original 3rd ed. 2016
Dimensions:
Height: 279mm,
Width: 210mm,
Weight: 1.539kg
ISBN: 9783319817057
ISBN 10: 3319817051
Series: Current Clinical Oncology
Pages: 596
Publication Date: 12 June 2018
Audience:
Professional and scholarly
,
Undergraduate
Format: Paperback
Publisher's Status: Active
Part A. Causes, Biological and Molecular bases of HCC Chapter 1. Epidemiology of Hepatocellular Carcinoma - Donna L. White, Fasiha Kanwal, Li Jiao and Hashem B. El-Serag Chapter 2. Environmental Carcinogens and Risk for Human Liver Cancer - John D. Groopman Chapter 3. Molecular Mechanisms of Hepatocellular Carcinoma - Hani Alotaibi, Nese Atabey, Kasim Diril, Esra Erdal and Mehmet Ozturk Chapter 4. Chemically-Induced Hepatocarcinogenesis - Yvonne P. Dragan Chapter 5. Molecular Profiling of Human Hepatocellular Carcinoma - Anuradha Budhu and Xin Wei Wang Chapter 6. Genomic signatures of risk factors and molecular identification of HCC subtypes - Jean-Charles Nault and Jessica Zucman-Rossi Chapter 7. MicroRNAs and hepatocellular carcinoma - Aldo Cavallini Chapter 8. Non-tumor prognostic factors in hepatocellular carcinoma - Nicolas Goossens, Ismail Labgaa and Augusto Villanueva Chapter 9. Gut microbiota and HCC - Sven H. Loosen, Christoph Roderburg and Tom Luedde Chapter 10. Hepatocellular Carcinoma as a Paradigm for a Systemic Evolutionary Approach to Cancer - Antonio Mazzocca, Giovanni Ferraro, Giovanni Misciagna and Brian I. Carr Chapter 11. HCC and its Microenvironment - Brian I. Carr Chapter 12. Circulating tumor cells (Liquid Tumor Biopsy) in hepatocellular carcinoma: biology, methodologies, and clinical implications - Zhengfen Yin Chapter 13. Role of the immune system in hepatocellular carcinoma: Implications for existing and novel therapies - Tobias Flecken and Robert Thimme Chapter 14. Inter- and Intratumor Heterogeneity in Hepatocellular Carcinoma - Evgeny V. Denisov, Tatiana S. Gerashchenko, Marina V. Zavyalova, Vasiliy N. Manskikh, Evgeny L. Choinzonov, Nadezhda V. Cherdyntseva and Vladimir M. Perelmuter Chapter 15. Systemic inflammation: a new prognostic domain and source of therapeutic targets in hepatocellular carcinoma - David J. Pinato and Rohini Sharma Chapter 16. Hepatocellular Carcinoma Associated with Hepatitis B virus - Inbal Houri and Oren Shibolet Chapter 18. Obesity, NASH and HCC - Chadia L. Robertson, Devanand Sarkar and Arun J. Sanyal Chapter 19. Metabolic Disease and Hepatocellular Carcinoma - David H. Van Thiel, Salamah Mohammad Alwahsh and Giuliano Ramadori Part B. DiagnosisChapter 21. Protein biomarkers in the management of hepatocellular carcinoma: Novel combinatory approaches - Philip Johnson and Sarah Berhane Chapter 22. Surveillance for hepatocellular carcinoma - Cristina Della Corte and Massimo Colombo Chapter 23. Use of Imaging Techniques to Screen for Hepatocellular Carcinoma - Satoshi Goshima Chapter 24. Ultrasound of Hepatocellular Carcinoma: The Important Contribution of Contrast Enhancement - Tae Kyoung Kim, Hyun-Jung Jang and Stephanie R. Wilson Chapter 25. MRI for Detection and Evaluation of Hepatocellular Carcinoma - Anuj Patel, Neil Malhotra, Christopher G. Roth, Sandeep Deshmukh and Donald G. Mitchell Chapter 26. Computed Tomography of HCC - Francesco Agnello and Giuseppe Brancatelli Chapter 27. Clinical features and clinician's diagnostic approach to hepatocellular carcinoma - Tamar Thurm and Oren Shibolet Chapter 28. Current HCC Staging systems: their uses and limitations - Yukio Tokumitsu and Hiroaki Nagano Part C. Therapies Chapter 29. Percutaneous Ethanol Injection - Tito Livraghi, Maria Franca Meloni and Anita Andreano Chapter 30. Thermal Ablative Treatments For Hepatocellular Carcinoma - Antonio Facciorusso and Michele Barone Chapter 31. Resection of Hepatocellular Carcinoma - Nir Lubezky, Yaacov Goykhman, Richard Nakache and Ido Nachmany Chapter 32. Liver Transplantation for Hepatocellular Carcinoma - Georg Gyoeri, Pierre-Alain Clavien and Mickael Lesurtel Chapter 33. Medical Therapy of HCC - Brian I. Carr, Srikanth Nagalla and Ravit Geva Chapter 34. Targeted therapies for Hepatocellular Carcinoma - Susan Kralian and Brian I. Carr Chapter 35. Radiation Therapy for Hepatocellular Carcinoma - Andrew S. Kennedy Chapter 36. Psychosocial Issues in Hepatocellular carcinoma - Jennifer L. Steel, Feridey N. Carr, Alexandra Savkova, Naadia Ahmed, Andrea DiMartini and Mary A. Dew Chapter 37. Bringing it all together - Brian I. Carr
Dr. Brian I. Carr is Professor of Medical Oncology, Thomas Jefferson University, Philadelphia and Professor, IRCCS de Bellis, National Institute for Digestive Diseases, Castellana Grotte (BA), Italy. Since 1977 he has devoted both his clinical activities and research science efforts to the clinical and scientific study of primary liver cancer (HCC or hepatocellular carcinoma). He has published more than 250 papers in peer-reviewed journals, over 350 abstracts and given a similar number of meeting presentations, written chapters in 36 books and edited 2 books. He is guest editor for the HCC special issue of Seminars in Oncology, Aug, 2012 and has written the chapter on HCC for the last 2 editions of Harrison’s Internal Medicine.
