Handbook of Proteases in Cancer

Cellular and Molecular Aspects

Sajal Chakraborti

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Hardback

Forthcoming
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English

CRC Press
13 December 2024

Forensic science; Oncology; Pharmacology; Biochemistry; Cellular biology (cytology)

This handbook provides comprehensive coverage of the role of proteases and the associated biochemical pathways in cancer development and metastasis. Proteases make up about 2% of the human genome and play a critical role in the tumor microenvironment. Handbook of Proteases in Cancer: Cellular and Molecular Aspects introduces the major classes of proteases and the signal transduction mechanisms associated with cancer initiation and progression. It discusses the role of inflammation and immune responses in proteases-induced cancer. The book covers cancer-induced gene expression and apoptotic and necrotic pathways in cancer. This is useful for researchers and professionals in cancer research, biochemistry, and physiology.

Key Features

• Provides insights on the roles of proteases and anti-proteases in the tumor microenvironment.

• Covers various cancer-induced apoptotic and necrotic pathways.

• Discusses the mechanisms by which proteases induce an increase in inflammation, immune

response, and gene expression.

• Covers the function of protease-activated receptors in cancer.

• Reviews the different gene expression pathways and the ways they become erratic during

protease-induced cancer.

Edited by: Sajal Chakraborti
Imprint: CRC Press
Country of Publication: United Kingdom
Dimensions: Height: 254mm, Width: 178mm,
ISBN: 9781032489537
ISBN 10: 1032489537
Pages: 449
Publication Date: 13 December 2024
Audience: College/higher education , Professional and scholarly , Primary , Undergraduate
Format: Hardback
Publisher's Status: Forthcoming

..I. General Aspects .. 1.1. Calpain as a therapeutic target in B-cell lymphoma and other malignant diseases. 1.2 Proteases in cancer: Theoretical insights on the proteases’ evolutionary pathway. 1. 3 Role of extracellular proteases in Glioblastoma . 1. 4 Metalloprotease in colon cancer proliferation and metastasis. 1.5 Role of proteolytic enzymes in colon cancer. 1.6. Tumor associated fibroblast and ADAMS orchestrate tumor microenvironment in hepatocellular carcinoma. 1.7 Unmasking the Protease Paradigm: Exploring the Molecular .Complexity of Proteases in Breast Cancer. 1. 8 Roles of MM7 in cancer. 1.9. The Role of Matrix Metalloproteinases MMP2 and MMP9 in Ovarian Cancer Progression. II. Signal Transduction Mechanisms..2.1. Role of calpains in cancer: an overview .2.2. Dual role of the ADAMTS family in breast cancer. 2.3. PKC isoforms and autophagy in cancer.2.4. Mechanistic insights into the ferroptotic regulation of ubiquitin specific proteases in gastrointestinal tumors.2.5. Serine proteases as critical modulators of the tumor microenvironment..2.6. Protease paradigm in cancer progression: Roles of Caspase-8 and matrix metalloproteinase family in cancer with special reference to head and neck squamous cell carcinoma..2.7. ENTPDs in the tumor microenvironment: A promising context for cancer diagnosis..2.8 Matrix Metalloproteases in Breast Cancer.2.9. Targeting EGFR-driven signaling of MMP-2 secretion for the management of metastatic cancers..: 2.10 Protease in Signal Transduction Mechanism in Cancer: Unraveling the Role of Proteolytic Enzymes in Tumor Progression. 2.11. Sirtuin inhibition modifies matrix metalloproteinases in cancer..2.12. 2.13 The role of matrix metalloproteinase in molecular and cellular aspects of oral squamous cell carcinoma...2.14 The dichotomous role of CHIP in cancer...III. Gene expression, apoptosis and necrosis..3.1 Mechanisms of apoptotic/necrotic cell death-related proteases: Cysteine and serine proteases.3.2. Apoptotic and non-apoptotic roles of caspases..3.3. Role of cysteine proteases and matrix metalloproteases in apoptosis and necrosis in cancer . 3.4. Role of SIRT1 in the regulation of gene expressions in breast cancer. .3.5. Future Vision of Protease Inhibitors in Context of Cocktail and Singular Therapy..3.6. Regulation of cell death by cysteine proteases in breast cancer. 3.7. Ubiquitin Specific Protease 7 (USP7) – Role in human pathologies and potential targeting opportunities in cancer

Dr. Sajal Chakraborti is a Professor at the Department of Biochemistry and Biophysics, University of Kalyani, Kalyani, West Bengal, India. He did postdoctoral research at the Johns Hopkins Medical Institution, New York Medical College, the University of Utah, and the University of Florida. He has over 35 years of teaching and independent research experience in Biochemistry and Cell Biology. He has published over 110 original research papers, 15 review articles, and 12 books.