Handbook of Mouse Mutations with Skin and Hair Abnormalities presents 48 mouse mutations that are all available to the biomedical community. Many of the mouse mutations with dermatological diseases are reviewed and illustrated in detail. This popular reference book gives you a single source to use when determining which mouse mutation will best serve your needs as a biomedical tool for sophisticated research projects.
The book also includes an overview of domestic animal genodermatoses to provide alternatives to mouse models that do not exist or to complement those that do. A detailed section written by renowned experts compares the biology of human and mouse skin and skin diseases in the areas of development and the use of animal models, mammalian genetics, keratin biochemistry, epidermal and hair follicle cycles and kinetics, cytokines and growth factors, keratinocyte culture systems, cutaneous carcinogenesis, cutaneous immune system, and skin changes associated with mutations of the endocrine system.
PART I. BIOLOGY OF SKIN AND HAIR OF LABORATORY MICE AND HUMAN BEINGS -- Introduction -- Chapter 1. Applications and Needs of Models for Dermatological Research /Lowell A. Goldsmith -- Chapter 2. Inbred Laboratory Mice as AnimaJ Models and Biomedical Tools: General Concepts /John P. Sundberg -- Chapter 3. The Jackson Laboratory Mouse Mutant Resource /Muriel T. Davisson -- Chapter 4. Hair Follicle Stem Cells /Robert M. Lavker, Tung-Tien Sun, and John P. Sundberg -- Chapter 5. The Mouse Skin as a Model for Chemical Carcinogenesis /Claudio J. Conti -- Chapter 6. Viral Induced Skin Tumors in Mice /John P. Sundberg, Hendrick G. Bedigian, and Roderick Bronson -- Chapter 7. Hair Types and Subtypes in the Laboratory Mouse /John P. Sundberg and Margaret E. Hogan -- Chapter 8. Growth Factors and Cutaneous Pathology /Lloyd E. King, Jr., Lillian B. Nanney, and Ronald E. Gates -- Chapter 9. Transgenic Mice with Cytokine Mutations Affecting the Skin /Manfred Blessing, Erby Wilkinson, and Brigid L. M. Hogan -- Chapter 10. Epidermal Keratins /Joseph A. Rothnagel and Dennis R. Roop -- Chapter 1 1. Hair Follicle Keratins /George E. Rogers and Barry C. Powell -- Chapter 12. Keratinocyte Cultures as Models for DermatologicaJ Disease /Mark R. Pittelkow -- Chapter 13. Mouse Mutations with Endocrine Functional Consequences /Wesley G. Beamer -- Chapter 14. The Immune System in Cutaneous Disease: the Search for a Mouse Model of the Lmmunopathology of Psoriasis /Susan F. Grammer and J. Wayne Streilein -- PART II. ANIMAL MODELS OF GENETIC BASED SKIN DISEASES Section A. Mouse Single Gene Mutations -- Introduction -- Chapter 1. The Adrenocortical Dysplasia (acd) Mutation, Chromosome 8 /John P. Sundberg, Seth J. Orlow, Hope O. Sweet, and Wesley G. Beamer -- Chapter 2. The Angora (go) Mutation, Chromosome 5 /John P. Sundberg -- Chapter 3. The Asebia (ab, ab1) Mutations, Chromosome 19 /John P. Sundberg -- Chapter 4. The Atrichosis (at) Mutation, Chromosome 10 /John P. Sundberg -- Chapter 5. The Balding (bal) Mutation, Chromosome 18 /John P. Sundberg -- Chapter 6. The Bare-Patches (Bpa) Mutation, Chromosome X /John P. Sundberg -- Chapter 7. The Bareskin (Bsk) Mutation, Chromosome 11 /John P. Sundberg -- Chapter 8. The Beige (bg) Mutation, Chromosome 13 /John P. Sundberg -- Chapter 9. The Caracul (Ca and Cad) Mutations, Chromosome 15 /John P. Sundberg and Hope O. Sweet -- Chapter 10. The Chronic Proliferative Dermatitis (cpd) Mutation, Chromosome ?. Harm HogenEsch, Marion J. J. Gijbels, and Chris Zurcher -- Chapter 11. The Crinkled (cr) Mutation, Chromosome 13 /John P. Sundberg -- Chapter 12. The Curly-Whiskers (cw) Mutation, Chromosome 9 /John P. Sundberg -- Chapter 13. The Depilated (dep) Mutation, Chromosome 4 /John P. Sundberg and Seth J. Orlow -- Chapter 14. The Downless (dl) and Sleek (Dlslk) Mutations, Chromosome 10 /John P. Sundberg -- Chapter 15. The Ferrochelatase Deficiency (FechmlPas) Mutation, Chromosome 18 /Xavier Montagutelli -- Chapter 16. The Flaky Skin (fsn) Mutation, Chromosome? /John P. Sundberg, Dawnalyn Boggess, Leonard D. Shultz, and Wesley G. Beamer -- Chapter 17. The Flaky Tail (ft) Mutation, Chromosome 3 /John P. Sundberg -- Chapter 18. The Frizzy (fr) Mutation, Chromosome 7 /John P. Sundberg -- Chapter 19. The Fuzzy (fz) Mutation, Chromosome 1 /John P. Sundberg -- Chapter 20. The Greasy (Gs) Mutation, Chromosome X /John P. Sundberg -- Chapter 21. The Hair Interior Defect (hid) Mutation, Chromosome? /John P. Sundberg -- Chapter 22. The Hairless (hr) and Rhino (hrrh) Mutations, Chromosome 14 /John P. Sundberg -- Chapter 23. The Hair Patches (Hpt) Mutation, Chromosome 4 /John P. Sundberg -- Chapter 24. The Hairy Ears (Eh) Mutation, Chromosome 15 /John P. Sundberg and Seth J. Orlow -- Chapter 25. The Harlequin (Hq) Mutation, Chromosome X /John P. Sundberg -- Chapter 26. The Ichthyosis (ic) Mutation, Chromosome 1 /John P. Sundberg and Mark R. Pittelkow -- Chapter 27. The Lethal Milk (Im) Mutation, Chromosome 2 /John P. Sundberg and Hope O. Sweet -- Chapter 28. The Lustrous ( / /) Mutation, Chromosome 11 /John P. Sundberg -- Chapter 29. The Matted (ma) Mutation, Chromosome 3 /John P. Sundberg -- Chapter 30. The Motheaten (me) and Viable Motheaten (mev) Mutations, Chromosome 6 /Leonard D. Shultz and John P. Sundberg -- Chapter 31. The Mottled Locus: Mottled (Mo), Blotchy (Mobl°), Brindled (Mobr), Dappled (Modp), Mosaic (Moms), Tortoiseshell (Mow), and Viable Brindled (Movbr) Mutations, Chromosome X / -- John P. Sundberg -- Chapter 32. The Naked (N) Mutation, Chromosome 15 /John P. Sundberg -- Chapter 33. The Nude (nu) and Streaker (nustr) Mutations, Chromosome 11 /John P. Sundberg -- Chapter 34. The Ragged (Ra) and Opossum (Raop) Mutations, Chromosome 2 /John P. Sundberg -- Chapter 35. The Repeated Epilation (Er) Mutation, Chromosome 4 /Jean-Louis Guenet, Josselyne Salaun, and Berthe Salzgeber -- Chapter 36. The Rex (Re), Wavy Coat (Rewl), and Denuded (Reden) Mutations, Chromosome 11 /John P. Sundberg -- Chapter 37. The Satin (sa) Mutation, Chromosome 13 /John P. Sundberg -- Chapter 38. The Scurfy (sf) Mutation, Chromosome X /Virginia L. Godfrey -- Chapter 39. The Severe Combined Immunodeficiency (scid) Mutation, Chromosome 16 /John P. Sundberg and Leonard D. Shultz -- Chapter 40. The Shaven (Sha) Mutation, Chromosome 15 /John P. Sundberg -- Chapter 41. The Silver (si) Mutation, Chromosome 10 /Seth J. Orlow and John P. Sundberg -- Chapter 42. The Soft Coat (soc) Mutation, Chromosome 3 /John P. Sundberg -- Chapter 43. The Sparse-Coat (spc) Mutation, Chromosome 14 /John P. Sundberg -- Chapter 44. The Sparse-Fur (Otcspf) and Abnormal Skin and Hair (Otcash) Mutations, Chromosome X /John P. Sundberg and Donald P. Doolittle -- Chapter 45. The Tabby (Ta), Tabby-c (Tal), and Tabby-J (TaJ) Mutations, Chromosome X /John P. Sundberg -- Chapter 46. The Tight-Skin (Tsk) Mutation, Chromosome 2 /John P. Sundberg -- Chapter 47. The Vitiligo (mivu) Mutant Allele of the Microphthalmia Locus, Chromosome 6 /M. Lynn Lamoreux and Seth J. Orlow -- Chapter 48. The Wellhaarig (we, weMr) Mutations, Chromosome 2 /John P. Sundberg -- Section B. Purported Polygenic Mouse Skin Diseases -- Introduction -- Chapter 1. Chronic Ulcerative Dermatitis in Black Mice /John P. Sundberg, Kathy S. Brown, and William M. McMahon -- Chapter 2. Barbering Behavioral Abnormalities in Inbred Laboratory Mice /William M. McMahon and John P. Sundberg -- Chapter 3. Alopecia Areata in Aging C3H /HeJ Mice /John P. Sundberg, Colleen M. Vallee, and Lloyd E. King, Jr. -- Section C. Nonmurine Animal Models of Genetic Based Skin Diseases -- Chapter 1. Selected Heritable Skin Diseases of Domesticated Animals /Robert W. Dunstan and Robert A. Kennis -- Index.
John P. Sundberg, D.V.M., Ph.D., is Head of the Pathology program at the Jackson Laboratory in Bar Harbor, Maine. Dr. Sundberg graduated in 1973 from the University of Vermont with a B.S. degree in Animal Science (summa cum laude) and obtained his D.V.M. degree in 1977 from Purdue University School of Veterinary Medicine, West Lafayette, Indiana. Following a brief period in private practice. Dr. Sundberg earned a Ph.D. degree in comparative pathology in 1981 from The University of Connecticut in Storrs. Dr. Sundberg served as an assistant professor at the University of Illinois College of Veterinary Medicine from 1981 to 1986. In 1986 he assumed his present position. Dr. Sundberg is a diplomate of the American College of Veterinary Pathologists. He is a member of the American Veterinary Medical Association, American Association for Laboratory Animal Science, Society for Investigative Dermatology, Hair Research Society, New England Veterinary Pathology Colloquy, and the Maine Veterinary Medical Association. Dr. Sundberg has been the recipient of research grants from the National Institutes of Health, American Cancer Society, National Alopecia Areata Foundation, and private industry. He has published over 125 research and clinical papers, 50 technical bulletins, and 15 book chapters. His current major research interests relate to mouse mutations as models of human and animal diseases, the comparative pathology and molecular evolution of nonhuman papillomaviruses, and spontaneous diseases of inbred laboratory mice.
