Handbook of Lung Targeted Drug Delivery Systems

Contents Editors ................................................................................................................ xi List of Contributors ............................................................................................. xiii Foreword............................................................................................................. xix Preface................................................................................................................. xxi 1 Introduction to Lung Physiology from a Drug Delivery Perspective.................................................................................1 Aparoop Das, Manash Pratim Pathak, Pompy Patowary, and Sanghita Das 2 Introduction to Pharmacology of the Lung from a Drug Delivery Perspective......................................................................................................................................................13 Caline McCarthy and Charles Preuss 3 Mechanism and Ways of Pulmonary Drug Administration .........................................................................................................................................................................29 Ahmed S. Fahad, Sai H.S. Boddu, and Jerry Nesamony 4 Transepithelial Route of Drug Delivery through the Pulmonary System...................................................................................................................................................................41 Sakshi Kumar and Swati Gupta 5 Understanding the Pharmacokinetics and Pharmacodynamics of Lung and Lung Drug Delivery ......................................................................................................53 Seth Kwabena Amponsah 6 Chronic Lung Diseases: Treatment, Challenges, and Solutions....................................................................................................................................................................................61 Aparoop Das, Riya Saikia, Kalyani Pathak, Urvashee Gogoi, and Surovi Saikia 7 Understanding of Lung Diseases with a Focus on Applications of Nano-particulate Drug Delivery Systems..................................................................................................73 Shraddha Khairnar, Mudassir Ansari, Ujwala Shinde, Agnivesh Shrivastava, and Kavita Singh 8 Model for Pharmaceutical Aerosol Transport through Stenosis Airway........................................................................................................................................................................91 Puchanee Larpruenrudee, Mohammad S. Islam, Gunther Paul, Akshoy R. Paul, Y. T. Gu, and Suvash C. Saha 9 Design of Efficient Dry Powder Inhalers.................... ...............................................................................................................................................................129 Anurag Tiwari, Akshoy R. Paul, Anuj Jain, and Suvash C. Saha 10 In Vivo Animal Models for Lung Targeted Drug Delivery Systems....................................................................................................................................................................155 Khushali Vashi, Jasmin Patel, and Yashwant Pathak 11 Advances in In Silico Study of Generic Orally Inhaled Drug Products........................................................................................................................................................................161 Hao Miao, Renjie Li, Xudong Zhou, Jiaqi Yu, Fen Huang, Haoqin Yang, and Zhenbo Tong 12 Effect of Aerosol Devices and Administration Techniques on Drug Delivery in a Simulated Spontaneously Breathing Pediatric Tracheostomy Model................171 Amelia Alberts and Charles Preuss 13 Pulmonary Drug Delivery: The Role of Polymeric Nanoparticles..........................................................................................................................................................................181 Ofosua Adi-Dako, Doris Kumadoh, Esther Eshun Oppong, Christina Osei Asare, and Mary Ann Archer 14 Polymeric Nanoparticle-Based Drug–Gene Delivery for Lung Cancer ....................................................................................................................................................................193 Keshav Moharir, Vinita Kale, Abhay Ittadwar, and Manash K. Paul 15 Inhalable Polymeric Nano-particulate Powders for Respiratory Delivery .............................................................................................................................................................209 Anita Patel and Jayvadan Patel vii 16 Recent Trends in Applications of Nano-Drug Delivery Systems....................................................................................................................................................................................225 Doris Kumadoh, Ofosua Adi-Dako, Yaa Asantewaa Osei, and Mary Ann Archer 17 Nanocarrier Systems for Lung Drug Delivery.................... ...............................................................................................................................................................239 Sai HS. Boddu and Jerry Nesamony 18 Nanomedicine for the Management of Pulmonary Disorders.................................................................................................................................................................................257 Pompy Patowary, Manash Pratim Pathak, Pronobesh Chattopadhyay, and Kamaruz Zaman 19 Recent Approaches in Dendrimer-Based Pulmonary Drug Delivery.........................................................................................................................................................................273 Rajiv Dahiya and Sunita Dahiya 20 Hybrid Lipid/Polymer Nanoparticles for Pulmonary Delivery of siRNA: Development and Fate Upon In Vitro Deposition on the Human Epithelial Airway Barrier ....................................................................................................................................................................................287 Samyak Nag, Shivani Baliyan, and Swati Gupta 21 Solid Lipid Nanoparticle-Based Drug Delivery for Lung Cancer ..........................................................................................................................................................................303 Deepa U. Warrier, Harita R. Desai, Kavita H. Singh, and Ujwala A. Shinde 22 Lipid-Based Pulmonary Delivery System: A Review and Future Considerations of Formulation Strategies and Limitations ........................................................................325 Komal Parmar and Jayvadan Patel 23 Respirable Controlled Release Polymeric Colloidal Nanoparticles..........................................................................................................................................................................337 Nazrul Islam and Abdur Rashid 24 Lung Clearance Kinetics of Liposomes and Solid Lipid Nanoparticles..........................................................................................................................................................................353 Soumalya Chakraborty, Sudipta Roy, Akash Dey, Sanjoy Kumar Das, Dhananjoy Saha, Subhabrata Ray, and Bhaskar Mazumder 25 Solid Lipid Nanoparticles for Sustained Pulmonary Delivery of Herbal Drugs for Lung Delivery: Preparation, Characterization, and In Vivo Evaluation ..................361 Nayanmoni Boruah, Himangshu Sharma, and Hemanta Kumar Sharma 26 Improved Solid Lipid Nano-formulations for Pulmonary Delivery of Paclitaxel for Lung Cancer Therapy .........................................................................................387 Samson A. Adeyemi, Pradeep Kumar, Viness Pillay, and Yahya E. Choonara 27 Anti-angiogenic Therapy for Lung Cancer: Focus on Bioassay Development in a Quest for Anti-VEGF Drugs................................................................................................409 Urvashi Bhati, Colin J. Barrow, Jagat R. Kanwar, Arnab Kapat, Venkata Ramana, and Rupinder K. Kanwar 28 Emerging Applications of Nanoparticles for Lung Cancer Diagnosis and Therapy ...........................................................................................................................................423 Raja Reddy, Bommareddy, Sheshanka Kesani, and Yashwant Pathak 29 Metallic Nanoparticles: Technology Overview and Drug Delivery Applications in Lung Cancer.....................................................................................................................433 Komal Parmar and Jayvadan Patel 30 Modeling of Pharmaceutical Aerosol Transport in the Targeted Region of Human Lung Airways Due to External Magnetic Field ...............................................................443 Anusmriti Ghosh, Mohammad S. Islam, Mohammad Rahimi-Gorji, Raj Das, and Suvash C. Saha 31 Phytochemicals and Biogenic Metallic Nanoparticles as Anti-cancer Agents in Lung Cancer ...................................................................................................................................459 Nana Ama Mireku-Gyimah, Rex Frimpong Anane, and Louis Hamenu 32 Pulmonary Applications and Toxicity of Engineered Metallic Nanoparticles ..........................................................................................................................................................471 Deepti Kaushalkumar Jani 33 Anti-cancer Activity of Eco-friendly Gold Nanoparticles against Lung and Liver Cancer Cells........................................................................................................483 Jayvadan Patel and Anita Patel viii Contents 34 Sub-chronic Inhalational Toxicity Studies for Gold Nanoparticles..........................................................................................................................................................................497 Srijan Mishra and Jigna Shah 35 Single-Use Dry Powder Inhalers for Pulmonary Drug Delivery...................................................................................................................................................................................503 Somchai Sawatdee and Teerapol Srichana 36 Lung Delivery of Nicotine for Smoking Cessation.................... .............................................................................................................................................................513 Hui Wang and Nazrul Islam 37 Formulation and Characterization of Dry Powder Inhalers for Pulmonary Drug Delivery ..............................................................................................................................527 Himangshu Sarma, Nayanmoni Boruah, and Hemanta Kumar Sharma 38 Devices for Dry Powder Drug Delivery to the Lung.................... ....................................................................................................................................................................539 Vimal Patel, Jigar Shah, Hiral Shah, and Jayvadan Patel 39 Numerical Modeling of Agglomeration and De-agglomeration in Dry Powder Inhalers ........................................................................................................................549 Tan Suwandecha and Teerapol Srichana 40 Oronasal and Tracheostomy Delivery of Soft Mist and Pressurized Metered-Dose Inhalers with Valved Holding Chamber..............................................................................557 Dasharath M. Patel, Unnati D. Chanpura, and Veer J. Patel 41 Modeling for Biopharmaceutical Performance in Lung Drug Discovery ......................................................................................................................................................................575 Amy Le, Kianna Samuel, Truong Tran, and Yashwant Pathak 42 Regulatory Consideration for Approval of Generic Inhalation Drug Products in the US, EU, Brazil, China, and India ..............................................................................579 Urvashi K. Parmar and Jayvadan Patel 43 Regulatory Perspectives and Concerns Related to Nanoparticle-Based Lung Delivery .....................................................................................................................................591 Johirul Islam, Hemanga Hazarika, Probin Kr Roy, Pompy Patowary Pronobesh Chattopadhyay, Yashwant V. Pathak, and Kamaruz Zaman 44 Clinical Controversies of Pediatric Aerosol Therapy...................................................................................................................................................................................611 Jeffrey Cruz and Charles Preuss 45 Drug Delivery Using Aerosols: Challenges and Advances in Neonatal Pediatric Subgroup ........................................................................................................................623 Surovi Saikia, Aparoop Das, and Yashwant Pathak 46 Safety and Toxicological Concerns Related to Nanoparticle-Based Lung Delivery .....................................................................................................................................631 Humera Memon, Vandit Shah, Tejal Mehta, and Jigna Shah 47 Nanoparticle-Based Lung Drug Delivery: A Clinical Perspective ..................................................................................643 Vandit Shah and Jigna Shah 48 European Perspective on Orally Inhaled Products: In Vitro Requirements for a Biowaiver ..................................................................................................................................653 Sunita Chaudhary, Dhaval Patel, Dasharath M. Patel, and Jayvadan K. Patel Index.................................................................................................................................................................................... 661