This handbook provides a unique overview of lipid membrane fundamentals and applications. The fascinating world of lipids that harbor and govern so many biological functionalities are discussed within the context of membrane structures, interactions, and shape evolution. Beyond the fundamentals in lipid science, this handbook focuses on how scientists are building bioinspired biomimetic systems for applications in medicine, cosmetics, and nanotechnology.
Key Features:
Includes experimental and theoretical overviews on the role of lipids, with or without associated biomolecules, as structural components imparting distinct membrane shapes and intermembrane interactions
Covers the mechanisms of lipid-membrane curvature, by peptide and protein binding, and the roles of signalling lipids and the cytoskeleton in plasma membrane shape evolution
Covers advanced X-ray and force measurement techniques
Discusses applications in biomedicine, cosmetics, and nanotechnology, including lipid vectors in nucleic acid, drug delivery in dermal applications, and lipid-based sensors and artificial biointerfaces
Covers artificial membranes from block copolymers, synthetic copolypeptides, and recombinant proteins
Includes an exciting section that explores the role of lipids in the origin of life in hydrothermal conditions
This book is a highly informative companion for professionals in biophysics, biochemistry, physical chemistry, and material and pharmaceutical sciences and bioengineering.
Preface. Editors. Contributors. Chapter 1 A Short History of Membrane Physics. Chapter 2 Structures and Interactions in Freely Suspended Multilayer Membranes and Dilute Lamellar Fluid Membranes from Synchrotron X-Ray Scattering. Chapter 3 Structures of Lipid Membranes: Cubic and Inverse Hexagonal Phases. Chapter 4 Structure of Lipid Membranes by Advanced X-Ray Scattering and Imaging. Chapter 5 Adhesion Protein Architecture and Intermembrane Potentials: Force Measurements and Biological Significance. Chapter 6 Charged Membranes: Poisson・Boltzmann Theory, the DLVO Paradigm, and Beyond. Chapter 7 Membrane Shape Evolution In Vitro. Chapter 8 Mechanisms of Membrane Curvature Generation by Peptides and Proteins: A Unified Perspective on Antimicrobial Peptides. Chapter 9 Lipid Membrane Shape Evolution and the Actin Cytoskeleton. Chapter 10 Effects of Osmotic Stress on Topologically Closed Membrane Compartments. Chapter 11 Cationic Liposomes as Spatial Organizers of Nucleic Acids in One, Two, and Three Dimensions: Liquid Crystal Phases with Applications in Delivery and Bionanotechnology. Chapter 12 Lipids in DNA, RNA, and Peptide Delivery for In Vivo Therapeutic Applications. Chapter 13 Electrostatics of Lipid Membranes Interacting with Oppositely Charged Macromolecules. Chapter 14 Lipid-Based Bioanalytical Sensors. Chapter 15 Lipids in Dermal Applications: Cosmetics and Pharmaceutics. Chapter 16 Supported Lipid Bilayers. Chapter 17 Artificial Membranes Composed of Synthetic Copolypeptides. Chapter 18 Synthetic Membranes from Block Copolymers, Recombinant Proteins, and Dendrimers. Chapter 19 Amphiphilic Self-Assembly and the Origin of Life in Hydrothermal Conditions. Index.
Cyrus R. Safinya is professor of physics at the University of California, Santa Barbara, USA. Joachim O. Rädler is professor of experimental physics at Ludwig-Maximilians-Universität München, Germany.
