Early Vascular Aging (EVA)

Section 1 – Introduction Historical Aspects and Biology of Aging PETER M. NILSSON The 9 paradigm shifts in cardiovascular aging research PIERRE BOUTOUYRIE AND PEDRO GUIMARAES CUNHA Vascular Aging and CV Disease PEDRO GUIMARAES CUNHA AND MICHAEL H. OLSEN Section 02 – Lifecourse approach and population based studies Aging Population: Challenges and Opportunities in a Life Course Perspective ANGELO SCUTERI AND PETER M. NILSSON Population-Based Studies: Milestones on the Epidemiological Timeline ERNST RIETZSCHEL AND MARC L. DE BUYZERE Lifetime Perspective of Vascular Aging a. Lessons from the Amsterdam Growth and Health Longitudinal Study ISABEL FERREIRA, ROEL J. VAN DE LAAR, FRANK C.T. VAN DER HEIDE, AND COEN D.A. STEHOUWER b. Cardiovascular Aging: Perspectives from Longitudinal Studies of Aging MAJD ALGHATRIF AND EDWARD G. LAKATTA c. Lessons from the Cardiovascular Risk in Young Finns Study COSTAN G. MAGNUSSEN, SUVI P. ROVIO, KATJA PAHKALA, AND OLLI T. RAITAKARI Early Vascular Aging in the Young ELAINE M. URBINA, PETER M. NILSSON, AND CARMEL M. MCENIERY Ethnicity and Arterial Function J. KENNEDY CRUICKSHANK AND NADIA BENNETT Section 03 – Molecular, Cellular and Mechanist Contributions to Vascular Aging Cellular and Molecular Determinants of Arterial Aging PATRICK LACOLLEY, PASCAL CHALLANDE, VERONIQUE REGNAULT, EDWARD G. LAKATTA, AND MINGYI WANG Platelet/Leukocyte–Vessel Wall Interactions and Early Aging VERONIQUE REGNAULT, JEREMY LAGRANGE, R€UMEYZA BASCETIN AND PATRICK LACOLLEY Age-Induced Endothelial Dysfunction and Intima-Media Thickening MICHAELA KOZAKOVA AND ARNO SCHMIDT-TRUKSASS Diabetes, Prediabetes, Metabolic Syndrome, and Large Artery Vascular Ageing COEN D.A. STEHOUWER, FRANK C.T. VAN DER HEIDE, MICHAELA KOZAKOVA, AND CARLO PALOMBO The Cross-Talk Between the Macro- and the Microcirculation STEPHANE LAURENT, DAMIANO RIZZONI,AND ENRICO AGABITI-ROSEI Changes in Peripheral Blood Pressure with Normal and Accelerated Aging S. FRANKLIN AND MICHAEL HECHT OLSEN Changes in Arterial Stiffness with Normal and Accelerated Aging ROSA MARIA BRUNO AND PIERRE BOUTOUYRIE Changes in Central Hemodynamics, Wave Reflection, and Heart_Vessel Coupling with Normal and Accelerated Aging THOMAS WEBER AND PATRICK SEGERS Arterial Stiffness and Blood Pressure Variability GIANFRANCO PARATI, JUAN EUGENIO OCHOA,GIUSEPPE SCHILLACI, AND PAOLO SALVI Chronic Inflammation in Atherosclerosis and Arteriosclerosis JAN ISABEL GONCALVESA, LUCA ZANOLI, JAN NILSSON, AND ANDREAS EDSFELDT Nonhemodynamic Components of EVA: Polycystic Ovary Syndrome (PCOS) IRENE LAMBRINOUDAKI and ELENA ARMENI Microbiota, Diet, Oral Health and Vascular Aging DAVIDE AGNOLETTI, FEDERICA PIANI, SILVIA TURRONI, AND MADELEINE JOHANSSON Section 04 – Biomarkers, risk prediction and phenotypes of vascular aging Traditional Versus New Models of Risk Prediction THOMAS BASTHOLM OLESEN AND MICHAEL HECHT OLSEN Estimated Arterial Stiffness JULIE VISHRAM-NIELSEN, DIMITRIOS TERENTES-PRINTZIOS, MICHAEL HECHT OLSEN, AND CHARALAMBOS VLACHOPOULOS Vascular Aging Biomarkers: Methodological Measurement Consensus and Reference Values PIERRE BOUTOUYRIE Imaging Biomarkers: Carotid Intima-Media Thickness and Aortic Stiffness as Predictors of Cardiovascular Disease CHARALAMBOS VLACHOPOULOS, GEORGIOS GEORGIOPOULOS, GEORGIOS MAVRAGANIS, KIMON STAMATELOPOULOS, AND COSTAS TSIOUFIS Imaging Biomarkers: Flow-Mediated Dilation as Predictor of Cardiovascular Disease ROSA MARIA BRUNO, SMRITI BADHWAR, ELISABETTA BIANCHINI, AND LORENZO GHIADONI Genetic Markers in Prediction of Cardiovascular Disease MARTIN W. MCBRIDE, DELYTH GRAHAM, SIMON FISHER, CARA TRIVETT, AND MANSHI ZHOU Phenotypes of Vascular Aging – Vascular Chronobiologic asynchrony PEDRO GUIMARA ES CUNHA, PETER M. NILSSON, PIERRE BOUTOUYRIE, MICHAEL HECHT OLSEN, AND STEPHANE LAURENT Section 05 – Vascular aging, organ damage and late stage disease Early and Late Stages of Chronic Kidney Disease in Relation to Arterial Changes AGNE-LAUCYTE-CIBULSKIENE AND MIKAEL GOTTS€ATER Arterial Aging, Blood Pressure, and Brain Damage ANGELO SCUTERI, STEPHANIE DEBETTE, AND ALBERTO AVOLIO Clinical Implications of Ventricular-Arterial Coupling and the Role of Therapeutic Interventions IGNATIOS IKONOMIDIS, GEORGE PAVLIDIS, AND DIMITRIOS VLASTOS Systemic Ventricular–Arterial Coupling and Heart Disease JULIO A. CHIRINOS Section 06 – Translating research into clinical practice, with precision cardiovascular medicine: Implications of vascular aging Vascular Aging and Clinical Trials PIERRE BOUTOUYRIE AND ROSA MARIA BRUNO a. PART I Treatment of Abnormalities in Lipid Metabolism and EVA VASILIOS KOTSIS b. Part II: Early Vascular Aging and Obesity Treatment JENS JORDAN c. Part III: Treatment with antidiabetes drugs—Effects on blood pressure and central hemodynamics PETER M. NILSSON d. Part IV: Arterial Stiffness as Treatment Target: The SPARTE Study STEPHANE LAURENT Lifestyle Intervention: What Works? PANAGIOTIS XAPLANTERIS AND CHARALAMBOS VLACHOPOULOS Targeting Blood Pressure Lowering and the Sympathetic Nervous System DAGMARA HERING AND KRZYSZTOF NARKIEWICZ Targeting Central Blood Pressure Through the Macro- and Microcirculation Cross-Talk STEPHANE LAURENT, ROSA MARIA BRUNO, CLAUDIA AGABITI-ROSEI, CAROLINA DE CIUCEIS, AND DAMIANO RIZZONI Cardiovascular Aging in Clinical Guidelines a. Cardiovascular Prevention Strategies in a Life Course Perspective PETER M. NILSSON b. Cardiovascular Prevention Strategies in Patients With Comorbidities (Metabolic, Chronic Inflammation, Immunomodulation, Cancer, and Treatment-Induced Arterial Changes) ANTONIOS ARGYRIS AND ATHANASE D. PROTOGEROU c. Cardiovascular Risk Prediction THOMAS BASTHOLM OLESEN AND MICHAEL HECHT OLSEN d. Target Organ Damage MARIA LORENZA MUIESAN AND CLAUDIA AGABITI ROSEI e. Therapeutic Implications of Early Vascular Aging PIERRE BOUTOUYRIE, ROSA MARIA BRUNO, AND STEPHANE LAURENT New Drugs Under Development for Cardiovascular Prevention STEPHANE LAURENT AND ULRIKE M. STECKELINGS Specific Pathways to Prevent Early Vascular Aging TINE DE BACKER, PIERRE BOUTOUYRIE, AND L VAN BORTEL Immunization, Vaccines, and Immunomodulation Section 07 – Global Mapping of Vascular Aging Research a. European Research Centres The ARTERY Society. The Association for Research Into Arterial Structure and Physiology THOMAS WEBER, CARMEL M. MCENIERY, ST_EPHANE LAURENT, AND JOHN COCKCROFT Clinical Pharmacology Unit—Hopital Europeen Georges Pompidou-APHP (Paris, France) PIERRE BOUTOUYRIE Lund University, Department of Clinical Sciences, Malmo, Sweden PETER M. NILSSON AND ISABEL GONCALVES Arterial Aging From Bedside to Bench ...and Back ANGELO SCUTERI The Maastricht study, The Netherlands: A population-based cohort study with oversampling of participants with type 2 diabetes COEN D.A. STEHOUWER Erasmus MC University Medical Center, Rotterdam, The Netherlands FRANCESCO MATTACE RASO Acute and Chronic Cardiovascular Deficiency, Nancy, France 000 PATRICK LACOLLEY Cardiology Department, Klinikum Wels-Grieskirchen, Wels, Austria THOMAS WEBER Department of Sport, Exercise and Health at University of Basel, Division of Sport and Exercise Medicine, Basel ARNO SCHMIDT-TRUCKSASS Biophysical Models for Medical Applications (BioMMedA), Ghent, Belgium PATRICK SEGERS Medical University of Gdansk, Poland KRZYSZTOF NARKIEWICZ Department of Geriatrics and Stroke Medicine, Brighton, UK C. RAJKUMAR Centre for the Research and Treatment of Arterial Hypertension and Cardiovascular Risk, Hospital Senhora da Oliveira/Minho University, Guimaraes, Portugal JORGE COTTER AND PEDRO GUIMARAES CUNHA Preventive Cardiology and Echocardiography Laboratory IGNATIOS IKONOMIDIS Institute of Preventive Pediatrics, Technical University of Munich, Munich, Germany RENATE OBERHOFFER-FRITZ Hypertension and Vascular Risk Unit, Internal Medicine Department, Hospital Clinic of Barcelona, Spain CRISTINA SIERRA AND MIGUEL CAMAFORT Unitat d’Hipertensio Arterial i Risc Vascular, Hospital del Mar, Universitat Pompeu Fabra, Barcelona, Spain ANNA OLIVERAS AND SUSANA VA ZQUEZ Nephrology, Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy LUCA ZANOLI CARDIO HEALTH-LAB: Cardiovascular Pathophysiology and Circulatory Health Laboratory RAFFAELE DE CATERINA AND CARLO PALOMBO Italian National Research Council (CNR), Institute of Clinical Physiology (IFC), Pisa Italy FABIO ANASTASIO RECCHIA AND ELISABETTA BIANCHINI Cardiovascular Internal Medicine, University of Bologna, Bologna, Italy CLAUDIO BORGHI Carvascare Research Group, Cuenca, Spain IVAN CAVERO-REDONDO Early Vascular Aging General Practitioner Research Centre, Budapest, Hungary JANOS NEMCSIK Cardiovascular Center, University Hospital Ghent, Belgium TINE DE BACKER Primary Care Research Unit of Salamanca (APISAL), Salamanca, Spain LUIS GARCIA ORTIZ ASKLEPIOS Study, Ghent, Belgium ERNST RIETZSCHEL AND PATRICK SEGERS Hypertension Excellence Center, Brescia, Italy MARIA LORENZA MUIESAN AND ANNA PAINI Laboratory of Vascular Biology, Clinica Medica, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy MARIA LORENZA MUIESAN AND CAROLINA DE CIUCEIS Department of Clinical and Experimental Medicine, University of Pisa, Italy STEFANO TADDEI AND LORENZO GHIADONI The Unit for Vascular Investigations, Vilnius University Santaros Klinikos, Lithuania LIGITA RYLISKYTE AND JOLITA BADARIENE Cardiovascular Prevention and Research Unit, Clinic and Laboratory of Pathophysiology, Department of Medicine, School of Health Sciences, National andKapodistrianUniversity of Athens ATHANASE D. PROTOGEROU SDCO—Steno Diabetes Center Odense, Odense, Denmark KURT HØJLUND Research Centre in Physical Activity, Health and Leisure (CIAFEL) LUCIMERE BOHN, JORGE MOTA, AND JOSE OLIVEIRA Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany JENS JORDAN Research Centre of Applied and Preventive Medicine/Centre for Population Health Research, Turku, Finland OLLI T. RAITAKARI Unit of Microbiome Science and Biotechnology, Department of Pharmacy and Biotechnology, University of Bologna, Bologna, Italy SILVIA TURRONI Menopause Unit, 2nd Department of Obstetrics and Gynecology, National and Kapodistrian University of Athens, Aretaieio Hospital, Athens, Greece IRENE LAMBRINOUDAKI Hypertension and Vascular Risk Unit, Internal Medicine Service, University Hospital of Sagunto, Sagunto (Valencia), Spain ENRIQUE RODILLA Population Science and Experimental Medicine, Institute of Cardiovascular Science, University College London, United Kingdom ALUN HUGHES Centre for Cardiovascular Health and Aging, Cardiff, United Kingdom BARRY J. MCDONNELL Peripheral Vessels Unit, First Department of Cardiology, National and Kapodistrian University of Athens, Medical School, Hippokration Hospital, Athens, Greece CHARALAMBOS VLACHOPOULOS b. Asia/Australia Research Centers Vascular Research Section, Department of Cardiology, Tokyo Medical University, Tokyo, Japan HIROFUMI TOMIYAMA Jichi Medical University Center of Excellence in Community Medicine Cardiovascular Research and Development (JCARD), Tochigi, Japan KAZUOMI KARIO Blood Pressure and Arterial Function (BPAF) Laboratory, Macquarie Medical School, Macquarie University, Sydney, Australia MARK BUTLIN Menzies Institute for Medical Research, Hobart, Australia RACHEL EMMA CLIMIE Menzies Institute for Medical Research, Hobart, Australia JAMES SHARMAN Miyagi University of Education Medical Center, and Tohoku University Graduate School of Medicine, Sendai, Japan JUNICHIRO HASHIMOTO 52. c. North American Research Centers History of North American Artery Society Preventive Cardiology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, United States ELAINE M. URBINA Iowa Translational Vascular Physiology Lab, Department of Health and Human Physiology, University of Iowa, Iowa City, United States GARY L. PIERCE Chirinos Lab at the University of Pennsylvania JULIO A. CHIRINOS, KATHERINE GREENE, AND HANNAH MAYNARD Integrative Human Physiology Laboratory, University of Massachusetts Boston, Boston, MA, United States TRACY BAYNARD AND BO FERNHALL Aging and Vascular Physiology Lab, Eugene, OR, United States ASHLEY WALKER UNC Cardiometabolic Lab, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States LEE STONER Integrative Physiology Laboratory, University of Illinois at Chicago, United States ROBERT W. MOTL 53. d. Latin American Research Centers ARTERY LATAM Society: Brief Historical Summary EDUARDO C.D. BARBOSA, PEDRO FORCADA, AND LUIS MARIA PUPI Clinic of Hypertension and Associated Metabolic Diseases—CHAMA, Rio de Janeiro, Brazil MARIO FRITSCH NEVES Hypertension Unity—Instituto do Coracao do HCFMUSP, Sao Paulo, Brazil LUIZ APARECIDO BORTOLOTTO Hypertension Unit. Cardiology Department, Medicine School, Federal University of Goias, Brazil WEIMAR KUNZ SEBBA BARROSO Research Group on Hypertension, Arterial Stiffness and Vascular Aging (GPHARV), Maringa, Brazil ROGERIO TOSHIRO PASSOS OKAWA, JAQUELINE LYRIO BERMUDES OKAWA, AND WENDELL ARTHUR LOPES Vascular Research Center and Its Risk Factors Vascor, Salvador, Bahia, Brazil LUCELIA BATISTA NEVES CUNHA MAGALHAES Laboratory of Vascular Dynamics and Non-Invasive Hemodynamics. Hosp. Sao Francisco—Santa Casa de Porto Alegre—Brazil EDUARDO COSTA DUARTE BARBOSA Cardiometabolic Center Dr. Luis Maria Pupi, Ciudad Autonoma de Buenos Aires, Argentina LUIS MARIA PUPI, FABIANA CALABRIA, AND PABLO MARIA PUPI CardioArenales: Noninvasive Vascular Laboratory PEDRO FORCADA, HORACIO ALMADA, AND RICARDO GARCIA Centro de Hipertension Arterial y Biomecanica Vascular FABIANA CALABRIA AND PABLO G. PIZZALA SICOR Clinical and Research Center, Medellin, Colombia DAGNOVAR ARISTIZABAL Metabolism and Biomechanics in Systemic Vasculopathy JAVIER OSVALDO SARY Arterial Stiffness Laboratory ERNESTO CARDONA MUNOZ AND CARLOS RAMOS BECERRA University Hospital, Fundacion Favaloro, Arterial Hypertension, Metabolic Unit RAMIRO SANCHEZ AND AGUSTI´N RAMIREZ Ricardo Gutierrez Children´s Hospital, Buenos Aires, Argentina SARDELLA ANGELA Masira Research Institute, Medical School, Universidad de Santander (UDES), Bucaramanga, Colombia PATRICIO LOPEZ-JARAMILLO 54. e. Network for Research in Vascular Aging CHRISTOPHER CLEMENS MAYER, JORDI ALASTRUEY, ROSA MARIA BRUNO, RACHEL EMMA CLIMIE, ANDREA GUALA, BERNHARD HAMETNER, IOANA MOZOS, CHLOE PARK, GIACOMO PUCCI, DIMITRIOS TERENTES-PRINTZIOS, AND ELISABETTA BIANCHINI