Practical, state-of-the-art pharmacokinetic research methods, ideas, advancements, applications, and strategies
Drawing on a wealth of extensive practical experience and theoretical research, Drug Metabolism and Pharmacokinetics encapsulates the most recent advancements and illustrative applications in the field. Sixty-eight relatively independent yet interconnected articles are included, each offering a unique perspective and providing in-depth interpretation. Readers can either read systematically or select specific topics of interest from the table of contents.
Basic concepts, frontier advancements, DMPK research strategies, and technical methods are covered for novel drug modalities and therapeutics in different disease areas. The book encompasses a wide range of application and validation cases for DMPK research, including studies in in vitro ADME, in vivo pharmacokinetics, metabolite profiling and identification, radiolabeled ADME, and bioanalysis. Case studies showing the application of topics covered are included throughout, along with valuable insights into problem-solving and critical thinking.
Written by a team of scientists specializing in DMPK research from the DMPK Department of WuXi AppTec, Drug Metabolism and Pharmacokinetics discusses sample topics including:
ADME characteristics, metabolite identification, and bioanalytical strategies for
oligonucleotide drugs Strategy and challenges in the determination of drug-to-antibody ratio (DAR) values and antibody-drug conjugates (ADCs) Breaking barriers in CNS drug development with intrathecal and intracerebroventricular administration Application and detection techniques of biomarkers in drug development Flux dialysis methods for assessing plasma protein binding of high protein-binding drugs
Drug Metabolism and Pharmacokinetics is an essential forward-thinking reference on the subject for pharmacy students, pharmaceutical industry researchers, and DMPK scientists, especially those exploring novel drug modalities.
By:
Liang Shen Imprint: John Wiley & Sons Inc Country of Publication: United States ISBN:9781394300129 ISBN 10: 1394300123 Pages: 704 Publication Date:30 April 2025 Audience:
Professional and scholarly
,
Undergraduate
Format:Hardback Publisher's Status: Forthcoming
Liang Shen, PhD, is the head of DMPK at WuXi AppTec.
