DNA Microarrays: A Practical Approach

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Mark Schena (Department of Biochemistry, Department of Biochemistry, Stanford University, USA)

DNA Microarrays

A Practical Approach

Mark Schena (Department of Biochemistry, Department of Biochemistry, Stanford University, USA)

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English

Oxford University Press
01 August 1999

Medical research; Pre-clinical medicine: basic sciences; Human biology; Genetic engineering; Parallel processing

Series: Practical Approach Series

DNA microarrays, or biochips, are small glass chips embedded with ordered rows of DNA and by providing a massive parallel platform for data gathering represent a fundamental technical advance in biomedical research. Such biochips enable the use of advanced fabrication, detection, and data mining technologies that allow data gathering at an unprecedented rate.

The first chapter is an introduction to the technology of DNA microarrays, emphasizing the methodological fundamentals of biochips. The next two chapters describe the use of confocal scanning in microarray detection and techniques for the efficient cloning and screening of differentially expressed genes. Chapter 4 describes assay optimization for enzymatic assays and chapter 5 antisense scanning arrays. This is followed by a chapter on the manufacture of molecular arrays using ink-jet printing technology. Chapter 7 describes gene expression analysis from cDNA microarrays and then chapter 8 covers the use of expression data in bioinformatics. Chapter 9 describes the use of active microelectronic arrays for DNA hybridization analysis and the last chapter details the use of microarray technology in pharmacogenomics.

This Practical Approach book is a comprehensive overview of the new and expanding field of DNA microarray technology and will be invaluable to any researcher interested in the use of biochips.

Edited by: Mark Schena (Department of Biochemistry Department of Biochemistry Stanford University USA)
Imprint: Oxford University Press
Country of Publication: United Kingdom
Volume: 205
Dimensions: Height: 235mm, Width: 157mm, Spine: 14mm
Weight: 409g
ISBN: 9780199637768
ISBN 10: 0199637768
Series: Practical Approach Series
Pages: 232
Publication Date: 01 August 1999
Audience: Professional and scholarly , Undergraduate
Format: Paperback
Publisher's Status: Active

Reviews for DNA Microarrays: A Practical Approach

'...it's an essential purchase and probably the cheapest one a microarraying lab will make' Microbiology Today '...With its well-laid out protocols, the book manages to instruct the reader well and should be accessible to both novice and expert molecular biologists alike' Aslib Book Guide