Design and Analysis of Pragmatic Trials

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Song Zhang (Univ of Texas SW Medical Center, USA) Chul Ahn (Univ of Texas SW Medical Center, USA)

Design and Analysis of Pragmatic Trials

Song Zhang (Univ of Texas SW Medical Center, USA), Chul Ahn (Univ of Texas SW Medical Center, USA), Hong Zhu (Prof at SW University, USA.)

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English

Chapman & Hall/CRC
16 May 2023

Clinical trials; Epidemiology & medical statistics; Probability & statistics; Biology, life sciences; Pharmaceutical technology

Series: Chapman & Hall/CRC Biostatistics Series

This book begins with an introduction of pragmatic cluster randomized trials (PCTs) and reviews various pragmatic issues that need to be addressed by statisticians at the design stage. It discusses the advantages and disadvantages of each type of PCT, and provides sample size formulas, sensitivity analyses, and examples for sample size calculation. The generalized estimating equation (GEE) method will be employed to derive sample size formulas for various types of outcomes from the exponential family, including continuous, binary, and count variables. Experimental designs that have been frequently employed in PCTs will be discussed, including cluster randomized designs, matched-pair cluster randomized design, stratified cluster randomized design, stepped-wedge cluster randomized design, longitudinal cluster randomized design, and crossover cluster randomized design. It demonstrates that the GEE approach is flexible to accommodate pragmatic issues such as hierarchical correlation structures, different missing data patterns, randomly varying cluster sizes, etc. It has been reported that the GEE approach leads to under-estimated variance with limited numbers of clusters. The remedy for this limitation is investigated for the design of PCTs. This book can assist practitioners in the design of PCTs by providing a description of the advantages and disadvantages of various PCTs and sample size formulas that address various pragmatic issues, facilitating the proper implementation of PCTs to improve health care. It can also serve as a textbook for biostatistics students at the graduate level to enhance their knowledge or skill in clinical trial design.

Key Features:

Discuss the advantages and disadvantages of each type of PCTs, and provide sample size formulas, sensitivity analyses, and examples.

Address an unmet need for guidance books on sample size calculations for PCTs;

A wide variety of experimental designs adopted by PCTs are covered;

The sample size solutions can be readily implemented due to the accommodation of common pragmatic issues encountered in real-world practice;

Useful to both academic and industrial biostatisticians involved in clinical trial design;

Can be used as a textbook for graduate students majoring in statistics and biostatistics.

By: Song Zhang (Univ of Texas SW Medical Center USA), Chul Ahn (Univ of Texas SW Medical Center, USA), Hong Zhu (Prof at SW University, USA.)
Imprint: Chapman & Hall/CRC
Country of Publication: United Kingdom
Dimensions: Height: 234mm, Width: 156mm,
Weight: 970g
ISBN: 9780367627355
ISBN 10: 0367627353
Series: Chapman & Hall/CRC Biostatistics Series
Pages: 206
Publication Date: 16 May 2023
Audience: Professional and scholarly , Undergraduate
Format: Hardback
Publisher's Status: Active

1. Pragmatic Randomized Trials 2. Cluster Randomized Trials 3. Matched-pair Cluster Randomized Design for Pragmatic Studies 4. Stratified Cluster Randomized Design for Pragmatic Studies 5. The GEE Approach for Stepped-Wedge Trial Design 6. The Mixed-Effect Model Approach and Adaptive Strategies for Stepped-Wedge Trial Design

Song Zhang, Ph.D. Professor, Peter O’Donnell Jr. School of Public Health, University of Texas Southwestern Medical Center. Chul Ahn, Ph.D. Professor, Peter O’Donnell Jr. School of Public Health, University of Texas Southwestern Medical Center. Hong Zhu, Ph.D. Professor, Department of Public Health Sciences, University of Virginia.