Biology and engineering meet in this groundbreaking and growing discipline
Biomedical engineering is an established interdisciplinary research and training area, combining various aspects of physiology, biology, materials science and engineering. Biomedical engineering programs and courses are integral parts of pertinent curricula, generating an urgent need for textbooks which can introduce this fundamental subject to new generations of students, researchers and practicing professionals.
The textbook Concepts of Tissue-Biomaterial Interactions meets this need with an introduction to the subject. Beginning with various, key, fundamental concepts of cellular biology and the physiology of tissue wound healing (required to understand interactions of tissues and implants) it offers essential information and insight regarding the design of successful biomaterial implants. Concluding with a look at the current forefront and future of the field, it is an indispensable introduction for fundamental and cutting-edge aspects of biomedical engineering applications.
Concepts of Tissue-Biomaterial Interactions readers will also find:
Introduction to biological aspects such as cell-extracellular matrix interactions and cell-substrate interactions Details regarding various aspects of the process of normal tissue wound healing
Current knowledge of tissue wound healing in the presence of implants Examples of pathological complications, including infection Design criteria for biocompatible implants The process of obtaining regulatory approval of new biomaterials and implantable medical devices by pertinent regulatory agencies Implant biomaterial and medical devices: past, present, and future
Concepts of Tissue-Biomaterial Interactions is recommended for advanced undergraduate and for graduate students interested in biomedical engineering, biomaterials, tissue engineering, and implantable biomaterials/medical devices, as well as a reference for practicing biomedical engineering professionals.
Introduction: Materials in Biomedical Applications Through the Ages The Tissue-Implant Interface Lessons Learned from Biology and Physiology Tissues and their Constituents Protein and Cell Interactions with Substrates • Proteins, Structure and Function in Body Fluids and Tissues • Cell Functions Pertinent to New Tissue Formation The Process of Normal Wound Healing of Injured Tissues • Blood, Blood Clotting and Fibrinolysis • White Blood Cells and Inflammation • Proliferation/Repair • Remodeling/Maturation Abnormal and/or Incomplete Wound Healing of Injured Tissues • The Proliferative Capacity of Cells • Stem Cells • Pathological Complications • Extracellular Matrix Abnormalities in Wound Healing Pathogens and Biofilm Formation • Clinical and Biomaterial-related Approaches to Combat Infections • Sterilization of Biomaterials and Implant Devices Evaluation of Biocompatibility • Chemical- and Mechanical- related Tests • In vitro Cell Models • Animal Tests • Clinical Trials • Local, Federal and International Standards and Regulations Implantable Device Considerations • Implant Retrieval and Evaluation • Degradable Implants • In situ implantation Frontiers in the Biomaterials Field • Biomimetic/Bioinspired Biomaterials • Nanostructured Biomaterials • “Responsive/Smart” Biomaterials • Protein-Engineered Biomaterials • Immunomodulatory Biomaterials
Rena Bizios, PhD, is a Professor in the Department of Biomedical Engineering at the University of Texas at San Antonio, San Antonio, TX. She has over four decades of experience teaching undergraduate and graduate courses regarding tissue-biomaterials interactions and related biomedical engineering topics. Marissa E. Wechsler, PhD, is an Assistant Professor in the Department of Biomedical Engineering at the University of Texas at San Antonio, San Antonio, TX. Her research interests focus on various aspects of biomaterials, specifically at the polymer-protein interface with applications in biosensing and drug delivery. She has also developed, and teaches, courses on soft biomaterials and stem cell engineering at the undergraduate and graduate levels.
