Computational Methods for Reproductive and Developmental Toxicology

Donald R. Mattison

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English

CRC Press
14 October 2024

Physical chemistry; Toxicology (non-medical)

Series: QSAR in Environmental and Health Sciences

Building from the perspective of reproductive and developmental biology, Computational Methods for Reproductive and Developmental Toxicology provides a timely and comprehensive overview of approaches in reproductive and developmental toxicology.

The book, which is part of the QSAR in Environmental and Health Sciences series, is divided into three broad sections. The first provides a review of methods and approaches to meet the need for safety assessments in product development and regulatory approaches for environmental chemicals. The next one reviews the biological processes and endpoints involved in reproduction and development.

The final and largest section summarizes protocols for evaluating biological processes and endpoints within reproduction and development. It also discusses informatics resources and computational methods.

The book takes a cross-disciplinary approach bringing together developmental, reproductive and systems biology, chemistry, toxicology, pharmacology, biostatistics, information sciences, bioinformatics, and computational approaches. This valuable resource provides those in the field with the necessary knowledge to evaluate both classic and recent approaches to characterize toxicity.

Edited by: Donald R. Mattison
Imprint: CRC Press
Country of Publication: United Kingdom
Dimensions: Height: 234mm, Width: 156mm,
Weight: 630g
ISBN: 9781032921891
ISBN 10: 1032921897
Series: QSAR in Environmental and Health Sciences
Pages: 342
Publication Date: 14 October 2024
Audience: Professional and scholarly , Undergraduate
Format: Paperback
Publisher's Status: Active

INTRODUCTION. Introduction. Visions and Advancements for Meeting the Needs of Safety Assessment of Pharmaceutical and Industrial Chemicals. REACH and Environmental Chemicals.REPRODUCTION AND DEVELOPMENT: BIOLOGICAL PROCESSES AND ENDPOINTS. Female Reproductive Physiology. Maternal Recognition of Pregnancy. Early Embryo Development and Bipotential Gonad Formation. Assessing the Reproductive Health of Men with Occupational Exposures. REPRODUCTION AND DEVELOPMENT: BIOLOGICAL AND COMPUTATIONAL METHODS. Animal Study Protocols and Alternative Assays for the Assessment of Reproductive and Developmental Toxicity. US National Library of Medicine Resources for Computational Toxicology. Modeling Endocrine Regulation of the Menstrual Cycle Using Delay Differential Equations. Molecular Structural Characteristics That Influence Partitioning of Xenobiotics into Human Breast Milk. Approaches for Pediatric Developmental Drug-Induced Liver Injury. Adverse Outcome Pathways for Developmental Toxicity.

Edited by Donald R. Mattison, National Institutes of Health, Bethesda, Maryland, USA, and Risk Sciences International, Ottawa, Ontario, Canada