Clinical Precision Medicine: A Primer

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Judy S. Crabtree (Associate Professor of Genetics, Scientific and Education Director, Precision Medicine Program, Director, School of Medicine Genomics Core)

Clinical Precision Medicine

A Primer

Judy S. Crabtree (Associate Professor of Genetics, Scientific and Education Director, Precision Medicine Program, Director, School of Medicine Genomics Core)

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English

Academic Press Inc
15 November 2019

Genetics (non-medical); DNA & Genome

Clinical Precision Medicine: A Primer offers clinicians, researchers and students a practical, up-to-date resource on precision medicine, its evolving technologies, and pathways towards clinical implementation. Early chapters address the fundamentals of molecular biology and gene regulation as they relate to precision medicine, as well as the foundations of heredity and epigenetics. Oncology, an early adopter of precision approaches, is considered with its relationship to genetic variation in drug metabolism, along with tumor immunology and the impact of DNA variation in clinical care.

Contributions by Stephanie Kramer, a Clinical Genetic Counselor, also provide current information on prenatal diagnostics and adult genetics that highlight the critical role of genetic counselors in the era of precision medicine.

Edited by: Judy S. Crabtree (Associate Professor of Genetics Scientific and Education Director Precision Medicine Program Director School of Medicine Genomics Core)
Imprint: Academic Press Inc
Country of Publication: United States
Dimensions: Height: 235mm, Width: 191mm,
Weight: 200g
ISBN: 9780128198346
ISBN 10: 0128198346
Pages: 112
Publication Date: 15 November 2019
Audience: Professional and scholarly , Undergraduate
Format: Paperback
Publisher's Status: Active

1. Chromosomes and Chromosomal Abnormalities 2. Molecular Genetics 3. Epigenetic Regulation 4. Heredity 5. Clinical Genetics 6. Pharmacogenomics 7. Immunogenomics

Dr. Crabtree received her PhD in Biochemistry from the University of Oklahoma where she was instrumental in sequencing portions of human chromosomes 9, 11 and 22 as part of the Human Genome Project. Her graduate work led to the identification of the gene for Multiple Endocrine Neoplasia, type 1 and she studied the mechanisms of endocrine tumor biology as a Postdoctoral Fellow at the National Human Genome Research Institute, National Institutes of Health under the direction of Dr. Francis Collins. Dr. Crabtree developed the first mouse models of MEN1, characterizing the endocrine pancreatic and parathyroid phenotypes associated with this disease model system. The study of endocrine tumor biology led to a position with Wyeth Pharmaceuticals Research and Development where she established a successful platform for drug development in uterine fibroids and developed mouse model systems to analyze tissue specific estrogenic compounds (TSECs) and androgenetic alopecia. She joined the LSUHSC Department of Genetics in 2009 to study pancreatic biology focusing on the mechanisms of pancreatic islet adaptation in diabetes, obesity and pregnancy as well as mechanisms of neuroendocrine tumorigenesis. Dr. Crabtree has published over 35 publications and was the recipient of the John Haddad Young Investigator Award from AIMM-ASBMR for her work on MEN1.

Reviews for Clinical Precision Medicine: A Primer

This is an excellent consultative resource that is brief and specific. It will be instrumental to readers looking for easy-to-read basic information on the current knowledge in precision medicine applied to human genetics. Dr. Crabtree has done an excellent job in editing this book. Congratulations on a great contribution. --Doody