Chimeric Toxins

Mechanisms of Action and Therapeutic Applications

Haya Lorberboum-Galski, Philip Lazarovici

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English

CRC Press
30 May 2002

Immunology; Pharmacology; Medical toxicology; Biochemical immunology; Toxicology (non-medical); Cellular biology (cytology)

Series: Cellular and Molecular Mechanisms of Toxic Action

Bacteria and plants produce powerful toxins that can cause a variety of diseases, some of which are lethal for many animal species. The mechanisms of action are common

to many of these toxins and represent general pathways for the interaction of a number of biomolecules with target cells, such as binding to specific surface receptors, internalization and translocation across the cell membrane, and interaction with intracellular components. Because of their potency in killing eukaryotic cells, they have been used in the development of novel agents for targeted immunotherapy, and have been termed 'chimeric toxins'.

The elucidation of the mechanism of action of protein toxins remains a complex problem,

but understanding these mechanisms will open new avenues for the design of novel therapies for the treatment of toxin-related diseases. In Chimeric Toxins: Mechanisms of Action and Therapeutic Applications, the authors review the structure, function and mechanisms of toxic action and investigate their therapeutic applications in medicine, including approaches used to design, express and purify these molecules as well as discussing their characteristics and in vivo efficacy.

Edited by: Haya Lorberboum-Galski, Philip Lazarovici
Imprint: CRC Press
Country of Publication: United Kingdom
Dimensions: Height: 254mm, Width: 178mm, Spine: 20mm
Weight: 734g
ISBN: 9780415283861
ISBN 10: 0415283868
Series: Cellular and Molecular Mechanisms of Toxic Action
Pages: 292
Publication Date: 30 May 2002
Audience: Professional and scholarly , Professional and scholarly , Professional & Vocational , Undergraduate , Further / Higher Education
Format: Hardback
Publisher's Status: Active

Haya Lorberboum-Galski, Philip Lazarovici