Chemotaxis Modeling of Autoimmune Inflammation

PDE Computer Analysis in R

William Schiesser

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English

CRC Press
29 July 2024

Epidemiology & medical statistics; Biomedical engineering; Applied mathematics; Biology, life sciences; Environmental science, engineering & technology

In response to an infection (e.g., from pathogens such as bacteria and viruses), the immune system can deplete macrophages (specialized white blood cells) and produce cytokines that are pro-inflammatory or anti-inflammatory. This counterproductive autoimmune response is represented mathematically as nonlinear chemotaxis diffusion.

This book is directed to the computer-based modeling of chemotaxis inflammation. The spatiotemporal analysis is

based on a model of three partial differential equations (PDEs).

The three PDE model is coded (programmed) as a set of routines in R, a quality, open-source, scientific programming system. The numerical integration (solution) of the PDEs is by the method of lines (MOL).

The three PDE model can be used for computer-based experimentation, for example, parameter variation and changes in the model equations or alternate models, to enhance a quantitative understanding of a postulated

inflammation.

This experimentation is illustrated by chapters pertaining to: (1) the computation and display of the PDE time derivatives, (2) the RHS terms of the PDEs with emphasis on the chemotaxis terms, (3) parameter variations to demonstrate parameter effects and sensitivities and (4) additonal terms in the PDEs to include PDE coupling and extensions of the basic PDE model.

By: William Schiesser
Imprint: CRC Press
Country of Publication: United Kingdom
Dimensions: Height: 234mm, Width: 156mm,
Weight: 280g
ISBN: 9781032317649
ISBN 10: 1032317647
Pages: 144
Publication Date: 29 July 2024
Audience: Professional and scholarly , Undergraduate
Format: Paperback
Publisher's Status: Forthcoming

1. PDE Chemotaxis Model Formulation. 2. PDE Chemotaxis Model Implementation. 3. Analysis of the Chemotaxis Model Time Derivatives. 4. Analysis of the Chemotaxis PDE Model Terms. 5. Sensitivity Analysis of the Chemotaxis. 6. Extensions of the Three PDE Chemotaxis Model. 7. Functions dss004, dss044. 8. Accuracy of Numerical PDE Solutions.

William E. Schiesser is Emeritus McCann Professor of Computational Biomedical Engineering, Chemical and Biomolecular Engineering and Professor of Mathematics at Lehigh University. His research is directed toward numerical methods and associated software for ordinary, differential-algebraic and partial differential equations (ODE/DAE/PDEs), and the development of mathematical models based on ODE/DAE/PDEs. He is the author, coauthor or coeditor of 30+ books, and his ODE/DAE/PDE computer routines have been accessed by thousands of colleges and universities, corporations and government agencies.