Cellular Lipid in Health and Disease presents a comprehensive and systematic coverage of the various roles lipids play in human biology.
This book is organized around the key roles lipids play in cellular biology, both in health and disease states. The first group of chapters is dedicated to the basic concepts of cellular lipids and the roles it plays in the cell, structure and physiology, storage, and utilization. The next set of chapters is focused on lipid metabolism, covering the organelles involved in lipid trafficking, cholesterol homeostasis, autophagy signaling, and metabolism in aging. The final group of chapters is dedicated to roles lipids play in specific disease states including diabetes, chronic kidney disease complications, obesity, heart diseases, nonalcoholic fatty liver disease, colorectal cancer, neurodegenerative diseases, B cell immunity, inflammation, viral infections, and other metabolic diseases.
Cellular Lipid in Health and Disease is a complete reference targeted at graduate students and early career researchers in cell biology, biochemistry, and pharmacology. Research physicians can also benefit from the foundational content and links to pathologies and therapeutic opportunities.
1 Structure and function of mammalian sphingolipids in health and disease Mariona Rabionet, Robert Engel and Roger Sandhoff 2 Intracellular lipid storage and utilization in adipocytes Vishva M. Sharma, James M. Ntambi and Vishwajeet Puri 3 Metabolic control by lipid droplet proteins Dilip Menon, Rakesh Mohan Jha, Arpita Nahak and Sheetal Gandotra 4 From endoplasmic reticulum to nucleus: the fate of cellular fatty acids Antoine Jutras-Carignan, Tania Guillemette and Catherine Mounier 5 Lipid trafficking and signaling in adipocytes Yan Tang and Qi-Qun Tang 6 Cell and molecular basis for maintenance of cholesterol homeostasis Townsend A. Smith and Russell A. DeBose-Boyd 7 Interplay between phospholipid signaling and autophagy Meenu Maan and Mainak Dutta 8 The role of cellular lipid metabolism in aging Xiaoli Chen and Jun Liu 9 Plasma lipid trafficking in type 2 diabetes Isabella James, Gina Wade, Helaina Von Bank, Ayren McGahee, Autumn Chevalier, Paula Gonzalez, Kayla Bote, James M. Ntambi and Judith Simcox 10 Lipotoxicity in the pathogenesis of chronic kidney disease complications Masashi Masuda, Yuji Shiozaki and Makoto Miyazaki 11 Cellular lipids in the molecular pathogenesis of obesity Mashudu G. Matumba, Ademola O. Ayeleso, James M. Ntambi and Emmanuel Mukwevho 12 Effects of cellular lipids on heart in pathology and physiology Volodymyr V. Balatskyi, Marcin Wolosiewicz, Aneta M. Dobosz, Zuzanna Tracz-Gaszewska, Adrian Sowka, Maria Kendziorek, Ewelina Krogulec, Viktor O. Navrulin and Pawel Dobrzyn 13 Uncoupling of fat deposition and inflammation during nonalcoholic fatty liver disease Honggui Li, Xinlei Guo, Eduardo Aquino and Chaodong Wu 14 Cellular lipids and colorectal cancer Seong-Ho Lee and Joseph LoBianco 15 Lipid metabolism in neurodegenerative diseases Jeroen F.J. Bogie, Jeroen Guns and Sam Vanherle 16 Cellular lipids in B cell immunity, inflammation, and cancer Yana Zhang, James M. Ntambi and Deyu Fang 17 Role of cellular fatty acids in combating the corona virus Abhishek Saxena and Archana Tiwari 18 Cellular lipids and viral infection Z. Zhang, C. Baguley, X. Wang and B. Kopek 19 Acetyl-CoA and acetylation in biology and disease Luigi Puglielli, Michael J. Rigby and Gonzalo Fernandez-Fuente 20 Role of omega-3 and -6 fatty acids in the inflammatory processes of obesity, hypertension, and autoimmunity F. Enrique Go´mez, Martha Kaufer-Horwitz, He´ctor Bourges and Gabriela E. Mancera-Chavez
Dr. James M. Ntambi is a Professor of Biochemistry and the Steenbock Professor of Nutritional Sciences, at the University of Wisconsin-Madison, as well as an Adjunct Professor of Biological Chemistry at Johns Hopkins University School of Medicine. The focus of Dr. Ntambi’s research is to understand the genetic regulation of metabolism, adipocyte biology, and differentiation. He is specifically interested in the genetic basis of obesity, cardiovascular disease, insulin resistance, and diabetes and how dietary factors, hormones, and environmental factors influence these disease states. Recently, his team has genetically engineered mice that are born without the stearoyl-CoA desaturase gene-1, and found that these mice resist obesity, diabetes, and fatty liver disease. Most recent work has focused on the role monounsaturated fatty acids in diet induced de novo lipogenesis, obesity, and insulin resistance. Dr. Ntambi also conducts research on obesity and diabetes and other noncommunicable metabolic diseases in developing countries. Dr. Ntambi has published more than 230 scientific articles in such journals including Journal of Biological Chemistry, Journal of Lipid Research, PNAS, Science, Cell Metabolism, Hepatology journal, BBRC, JCI, BBA, PLoS, Journal of Nutrition, and American Journal of Physiology-Endocrinology and Metabolism, among others.
