Caspases as Molecular Targets for Cancer Therapy discusses the recent developments on targeted therapies for cancer using caspases. It describes the selection of specific caspases for cancer therapy with the current standard of care and highlights numerous assay techniques for caspase activities.
This book discusses topics such as mutations within apoptosis gene, inflammatory caspases, tumor suppression, and the different caspase types and their role in anticancer activity. In addition, it discusses caspase activity assay procedure and future perspectives.
It is a valuable resource for researchers, students, and members of biomedical and medical fields who want to learn more about novel anticancer targeted therapies.
1. Introduction to Caspases, its function, mechanism, and classification 2. Mutations within apoptosis gene and caspases 3. Inflammatory caspases -1, -4, and -5 and their role in anticancer activity 4. Caspase-2 and tumor suppression 5. Caspase-3: A promising target for anticancer agents 6. Caspase-7 mutations and its activators 7. Re-instating the expression and activation of caspase-8 and caspase-10 in cancer therapy 8. Caspase-9 gene mutation and its activators 9. Caspases activity assay procedure 10. Current and future prospective of caspases targeting in cancer therapy
Dr. Ankur Vaidya obtained his PhD from Dr. H.S. Gour University, when he researched design, synthesis, and screening of a few quinoline and oxadiazole derivatives for anticancer activities. He has 12 years of experience in teaching and research, and already supervised 18 PhD students. He wrote 5 book chapters and co-authored 2 books, including Nanotechnology Applications for Cancer Chemotherapy (Elsevier, 2020).